Background: Not all breast cancer patients benefit from neoadjuvant or adjuvant therapy,
resulting in considerable undertreatment or overtreatment. New insights into the role of tumor-…

Research in different species has shown that Polo-like kinases are essential for successful
cell division. In human cells, Polo-like kinase-1 (Plk1) has been implicated in the regulation of …

Genomic and chromosomal instability are hallmarks of cancer and shape the genomic
composition of cancer cells, thereby determining their behavior and response to treatment. …

… 16 known ATM substrates, we correctly predicted 39. In addition, we predicted 12 new ATM
sites … in 6 proteins not previously known to be ATM substrates. One of these novel predicted …

Chromosomal instability (CIN) drives cancer cell evolution, metastasis and therapy resistance,
and is associated with poor prognosis 1 . CIN leads to micronuclei that release DNA into …

DNA damage triggers multiple checkpoint pathways to arrest cell cycle progression. Less is
known about the mechanisms that allow resumption of the cell cycle once checkpoint …

Many cancer-associated somatic copy number alterations (SCNAs) are known. Currently,
one of the challenges is to identify the molecular downstream effects of these variants. …

DNA damage checkpoints arrest cell cycle progression to facilitate DNA repair. The ability to
survive genotoxic insults depends not only on the initiation of cell cycle checkpoints but also …

14-3-3 proteins are crucial in a wide variety of cellular responses including cell cycle
progression, DNA damage checkpoints and apoptosis. One particular 14-3-3 isoform, σ, is a p53-…

Following genotoxic stress, cells activate a complex kinase-based signaling network to
arrest the cell cycle and initiate DNA repair. p53-defective tumor cells rewire their checkpoint …