User profiles for Manolis Maragkakis

Emmanouil (Manolis) Maragkakis

Stadtman Principal Investigator, NIA/NIH
Verified email at nih.gov
Cited by 5926

Lost in translation: an assessment and perspective for computational microRNA target identification

P Alexiou, M Maragkakis, GL Papadopoulos… - …, 2009 - academic.oup.com
MicroRNAs (miRNAs) are a class of short endogenously expressed RNA molecules that
regulate gene expression by binding directly to the messenger RNA of protein coding genes. …

DIANA-microT web server: elucidating microRNA functions through target prediction

M Maragkakis, M Reczko, VA Simossis… - Nucleic acids …, 2009 - academic.oup.com
Computational microRNA (miRNA) target prediction is one of the key means for deciphering
the role of miRNAs in development and disease. Here, we present the DIANA-microT web …

TarBase 6.0: capturing the exponential growth of miRNA targets with experimental support

…, P Alexiou, G Georgakilas, M Maragkakis… - Nucleic acids …, 2012 - academic.oup.com
As the relevant literature and the number of experiments increase at a super linear rate,
databases that curate and collect experimentally verified microRNA (miRNA) targets have …

DIANA miRPath v. 2.0: investigating the combinatorial effect of microRNAs in pathways

…, G Georgakilas, M Reczko, M Maragkakis… - Nucleic acids …, 2012 - academic.oup.com
MicroRNAs (miRNAs) are key regulators of diverse biological processes and their functional
analysis has been deemed central in many research pipelines. The new version of DIANA-…

Functional microRNA targets in protein coding sequences

M Reczko, M Maragkakis, P Alexiou, I Grosse… - …, 2012 - academic.oup.com
Motivation: Experimental evidence has accumulated showing that microRNA (miRNA)
binding sites within protein coding sequences (CDSs) are functional in controlling gene …

[HTML][HTML] Accurate microRNA target prediction correlates with protein repression levels

M Maragkakis, P Alexiou, GL Papadopoulos… - BMC …, 2009 - Springer
Background MicroRNAs are small endogenously expressed non-coding RNA molecules
that regulate target gene expression through translation repression or messenger RNA …

DIANA-LncBase: experimentally verified and computationally predicted microRNA targets on long non-coding RNAs

…, N Kostoulas, M Reczko, M Maragkakis… - Nucleic acids …, 2013 - academic.oup.com
Recently, the attention of the research community has been focused on long non-coding
RNAs (lncRNAs) and their physiological/pathological implications. As the number of …

DIANA-mirPath: Integrating human and mouse microRNAs in pathways

GL Papadopoulos, P Alexiou, M Maragkakis… - …, 2009 - academic.oup.com
DIANA-mirPath is a web-based computational tool developed to identify molecular pathways
potentially altered by the expression of single or multiple microRNAs. The software …

[HTML][HTML] Editing of Epstein-Barr virus-encoded BART6 microRNAs controls their dicer targeting and consequently affects viral latency

H Iizasa, BE Wulff, NR Alla, M Maragkakis… - Journal of Biological …, 2010 - ASBMB
Certain primary transcripts of miRNA (pri-microRNAs) undergo RNA editing that converts
adenosine to inosine. The Epstein-Barr virus (EBV) genome encodes multiple microRNA …

Mili and Miwi target RNA repertoire reveals piRNA biogenesis and function of Miwi in spermiogenesis

…, Q Zheng, P Alexiou, M Maragkakis… - Nature structural & …, 2012 - nature.com
Germ cells implement elaborate mechanisms to protect their genetic material and to
regulate gene expression during differentiation. Piwi proteins bind Piwi-interacting RNAs (piRNAs), …