RNA binding proteins (RBPs) control the fate and expression of a transcriptome. Despite
this fundamental importance, our understanding of plant RBPs is rudimentary, being mainly …

Following the realization that eukaryotic RNA-binding proteomes are substantially larger than
anticipated, we must now understand their detailed composition and dynamics. Methods …

Mycobacteria are characterized by their impermeable outer membrane, which is rich in mycolic
acids 1. To transport substrates across this complex cell envelope, mycobacteria rely on …

Mast cells are rare tissue-resident cells of importance to human allergies. To understand the
structural basis of principle mast cell functions, we analyzed the proteome of primary human …

The ESX-5 type VII secretion system is a membrane-spanning protein complex key to the
virulence of mycobacterial pathogens. However, the overall architecture of the fully assembled …

Intracellular bacterial pathogens inject effector proteins to hijack host cellular processes and
promote their survival and proliferation. To systematically map effector-host protein-protein …

Cellular stress causes multifaceted reactions to trigger adaptive responses to environmental
cues at all levels of the gene expression pathway. RNA-binding proteins (RBP) are key …

Most microbial species, including model eukaryote Saccharomyces cerevisiae, possess
genetic capability to utilize many alternative nutrient sources. Yet, it remains an open question …

ARS2 is a highly conserved metazoan protein involved in numerous aspects of nuclear
RNA metabolism. As a direct partner of the nuclear cap-binding complex (CBC), it mediates …

Successful pathogens use complex signaling mechanisms to monitor their environment and
reprogram global gene expression during specific stages of infection. Group A …