Frequent pathway mutations of splicing machinery in myelodysplasia
…, M Otsu, N Obara, M Sakata-Yanagimoto… - Nature, 2011 - nature.com
Myelodysplastic syndromes and related disorders (myelodysplasia) are a heterogeneous
group of myeloid neoplasms showing deregulated blood cell production with evidence of …
group of myeloid neoplasms showing deregulated blood cell production with evidence of …
Somatic RHOA mutation in angioimmunoblastic T cell lymphoma
M Sakata-Yanagimoto, T Enami, K Yoshida… - Nature …, 2014 - nature.com
Angioimmunoblastic T cell lymphoma (AITL) is a distinct subtype of peripheral T cell
lymphoma characterized by generalized lymphadenopathy and frequent autoimmune-like …
lymphoma characterized by generalized lymphadenopathy and frequent autoimmune-like …
Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity
…, H Kojima, H Yagita, M Sakata-Yanagimoto… - Nature …, 2008 - nature.com
The acquisition of cytotoxic effector function by CD8 + T cells is crucial for the control of
intracellular infection and tumor invasion. However, it remains unclear which signaling pathways …
intracellular infection and tumor invasion. However, it remains unclear which signaling pathways …
Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms
…, A Tamura, H Honda, M Sakata-Yanagimoto… - Nature, 2009 - nature.com
Acquired uniparental disomy (aUPD) is a common feature of cancer genomes, leading to
loss of heterozygosity. aUPD is associated not only with loss-of-function mutations of tumour …
loss of heterozygosity. aUPD is associated not only with loss-of-function mutations of tumour …
Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms
…, M Otsu, N Obara, M Sakata-Yanagimoto… - Nature …, 2013 - nature.com
Cohesin is a multimeric protein complex that is involved in the cohesion of sister chromatids,
post-replicative DNA repair and transcriptional regulation. Here we report recurrent …
post-replicative DNA repair and transcriptional regulation. Here we report recurrent …
[HTML][HTML] Molecular heterogeneity in peripheral T-cell lymphoma, not otherwise specified revealed by comprehensive genetic profiling
…, H Makishima, M Sanada, M Sakata-Yanagimoto… - Leukemia, 2019 - nature.com
Peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS) is a diagnosis of exclusion,
being the most common entity in mature T-cell neoplasms, and its molecular pathogenesis …
being the most common entity in mature T-cell neoplasms, and its molecular pathogenesis …
Gain‐of‐function mutations and copy number increases of Notch2 in diffuse large B‐cell lymphoma
…, S Ota, Y Ota, K Izutsu, M Sakata‐Yanagimoto… - Cancer …, 2009 - Wiley Online Library
Signaling through the Notch1 receptor has a pivotal role in early thymocyte development.
Gain of Notch1 function results in the development of T‐cell acute lymphoblastic leukemia in a …
Gain of Notch1 function results in the development of T‐cell acute lymphoblastic leukemia in a …
[HTML][HTML] Activation of RHOA–VAV1 signaling in angioimmunoblastic T-cell lymphoma
M Fujisawa, M Sakata-Yanagimoto, S Nishizawa… - Leukemia, 2018 - nature.com
Somatic G17V RHOA mutations were found in 50–70% of angioimmunoblastic T-cell
lymphoma (AITL). The mutant RHOA lacks GTP binding capacity, suggesting defects in the …
lymphoma (AITL). The mutant RHOA lacks GTP binding capacity, suggesting defects in the …
Variegated RHOA mutations in adult T-cell leukemia/lymphoma
…, A Kitanaka, M Sakata-Yanagimoto… - Blood, The Journal …, 2016 - ashpublications.org
Adult T-cell leukemia/lymphoma (ATLL) is a distinct form of peripheral T-cell lymphoma with
poor prognosis, which is caused by the human T-lymphotropic virus type 1 (HTLV-1). In …
poor prognosis, which is caused by the human T-lymphotropic virus type 1 (HTLV-1). In …
Direct reprogramming improves cardiac function and reverses fibrosis in chronic myocardial infarction
…, M Seki, Y Suzuki, M Fujisawa, M Sakata-Yanagimoto… - Circulation, 2023 - Am Heart Assoc
Background: Because adult cardiomyocytes have little regenerative capacity, resident cardiac
fibroblasts (CFs) synthesize extracellular matrix after myocardial infarction (MI) to form …
fibroblasts (CFs) synthesize extracellular matrix after myocardial infarction (MI) to form …