User profiles for Majid Hafezparast
Majid HafezparastUniversity of Sussex Verified email at sussex.ac.uk Cited by 4976 |
Genealogies of mouse inbred strains
JA Beck, S Lloyd, M Hafezparast, M Lennon-Pierce… - Nature …, 2000 - nature.com
The mouse is a prime organism of choice for modelling human disease. Over 450 inbred
strains of mice have been described, providing a wealth of different genotypes and phenotypes …
strains of mice have been described, providing a wealth of different genotypes and phenotypes …
Mutations in dynein link motor neuron degeneration to defects in retrograde transport
M Hafezparast, R Klocke, C Ruhrberg, A Marquardt… - Science, 2003 - science.org
Degenerative disorders of motor neurons include a range of progressive fatal diseases such
as amyotrophic lateral sclerosis (ALS), spinal-bulbar muscular atrophy (SBMA), and spinal …
as amyotrophic lateral sclerosis (ALS), spinal-bulbar muscular atrophy (SBMA), and spinal …
A mutation in dynein rescues axonal transport defects and extends the life span of ALS mice
D Kieran, M Hafezparast, S Bohnert, JRT Dick… - The Journal of cell …, 2005 - rupress.org
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition characterized by
motoneuron degeneration and muscle paralysis. Although the precise pathogenesis of ALS …
motoneuron degeneration and muscle paralysis. Although the precise pathogenesis of ALS …
[HTML][HTML] Neurobiology of axonal transport defects in motor neuron diseases: Opportunities for translational research?
KJ De Vos, M Hafezparast - Neurobiology of disease, 2017 - Elsevier
Intracellular trafficking of cargoes is an essential process to maintain the structure and
function of all mammalian cell types, but especially of neurons because of their extreme axon/…
function of all mammalian cell types, but especially of neurons because of their extreme axon/…
PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage
…, F Gomez-Herreros, M Hafezparast… - Nucleic acids …, 2014 - academic.oup.com
Amyotrophic lateral sclerosis (ALS) is associated with progressive degeneration of motor
neurons. Several of the genes associated with this disease encode proteins involved in RNA …
neurons. Several of the genes associated with this disease encode proteins involved in RNA …
SHIRPA, a protocol for behavioral assessment: validation for longitudinal study of neurological dysfunction in mice
…, S Ball, SJ Nicholson, AS Witherden, M Hafezparast… - Neuroscience …, 2001 - Elsevier
Mouse models of neurological abnormalities are only valuable if accurately assessed. The
three-stage SHIRPA procedure is used for the standardised assessment of mouse phenotype …
three-stage SHIRPA procedure is used for the standardised assessment of mouse phenotype …
[PDF][PDF] Mutations in BICD2 cause dominant congenital spinal muscular atrophy and hereditary spastic paraplegia
Dominant congenital spinal muscular atrophy (DCSMA) is a disorder of developing anterior
horn cells and shows lower-limb predominance and clinical overlap with hereditary spastic …
horn cells and shows lower-limb predominance and clinical overlap with hereditary spastic …
[HTML][HTML] Cytoplasmic dynein heavy chain: the servant of many masters
G Schiavo, L Greensmith, M Hafezparast… - Trends in …, 2013 - cell.com
Cytoplasmic dynein is the main retrograde motor in all eukaryotic cells. This complex comprises
different subunits assembled on a cytoplasmic dynein heavy chain 1 (DYNC1H1) dimer. …
different subunits assembled on a cytoplasmic dynein heavy chain 1 (DYNC1H1) dimer. …
Novel mutations expand the clinical spectrum of DYNC1H1-associated spinal muscular atrophy
…, M Pitt, C Sewry, R Phadke, M Hafezparast… - Neurology, 2015 - AAN Enterprises
Objective: To expand the clinical phenotype of autosomal dominant congenital spinal muscular
atrophy with lower extremity predominance (SMA-LED) due to mutations in the dynein, …
atrophy with lower extremity predominance (SMA-LED) due to mutations in the dynein, …
A comprehensive assessment of the SOD1G93A low-copy transgenic mouse, which models human amyotrophic lateral sclerosis
…, A Parker, A Gray, M Hafezparast… - Disease models & …, 2011 - journals.biologists.com
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that results
in the death of motor neurons in the brain and spinal cord. The disorder generally strikes in …
in the death of motor neurons in the brain and spinal cord. The disorder generally strikes in …