Cardiolipin is a unique phospholipid with dimeric structure, carrying four acyl groups and two
negative charges. It is exclusively found in bacterial and mitochondrial membranes, which …

In this article, the formation of prokaryotic and eukaryotic cardiolipin is reviewed in light of its
biological function. I begin with a detailed account of the structure of cardiolipin, its …

Barth syndrome is an X-linked recessive disease caused by mutations in the tafazzin gene.
Patients have reduced concentration and altered composition of cardiolipin, the specific …

… 0.25m sucrose, 20 mm KCl, 20 mmTris-HCl, 0.5 mm EDTA, 10 mm glucose, 4 mm NaPO
4 , and 3 mm… Further additives were 0.5 mg of BSA, 10 μm AP 5 S, 50 μm ADP, and 3 units/ml …

Cardiolipin is a unique mitochondrial phospholipid with an atypical fatty acid profile, but the
significance of its acyl specificity has not been understood. We explored the enormous …

… Whole animals or cells were homogenized with a tight-fitting Teflon glass homogenizer in
isolation buffer containing 210 mm mannitol, 70 mm sucrose, 1 mm EGTA, and 5 mm Hepes (…

Barth syndrome is an X‐linked cardiac and skeletal mitochondrial myopathy. Barth syndrome
may be due to lipid alterations because the product of the mutated gene is homologous to …

Considerable progress has recently been made in understanding the role of cardiolipin in
mitochondria. In this brief review, we discuss new data that show how cardiolipin specifically …

Since it has been recognized that mitochondria are crucial not only for energy metabolism
but also for other cellular functions, there has been a growing interest in cardiolipin, the …

F 1 F 0 ATP synthase forms dimers that tend to assemble into large supramolecular structures.
We show that the presence of cardiolipin is critical for the degree of oligomerization and …