Aging is emerging as a druggable target with growing interest from academia, industry and
investors. New technologies such as artificial intelligence and advanced screening …

Reversing or slowing the aging process brings great promise to treat or prevent age‐related
disease, and targeting the hallmarks of aging is a strategy to achieve this. Epigenetics …

Since the identification and definition of the hallmarks of aging, these aspects of molecular
and cellular decline have been most often described as isolated or distinct mechanisms. …

Slowing down translation in either the cytosol or the mitochondria is a conserved longevity
mechanism. Here, we found a non-interventional natural correlation of mitochondrial and …

… A stock of concentration of 1 M glycine and serine was made by dissolving glycine and serine
in water. The pH of glycine and serine stock solution was adjusted to 6.0–6.5 with sodium …

The human population is aging, and the need for interventions to slow progression of age-related
diseases (geroprotective interventions) is growing. Repurposing compounds already …

XTcf-3 is a maternally expressed Xenopus homolog of the mammalian HMG box factors Tcf-1
and Lef-1. The N-terminus of XTcf-3 binds to β-catenin. Microinjection of XTcf-3 mRNA in …

Tcf/Lef transcription factors mediate signalling from Wingless/Wnt proteins by recruiting
Armadillo/β-catenin as a transcriptional co-activator 1 , 2 , 3 , 4 , 5 , 6 , 7 . However, studies of …

… m near the sea surface to 300 m in the deep ocean. The ocean in this model includes a free
surface, thus allowing the air-sea interface to evolve freely and permitting the use of realistic, …

Tcf transcription factors interact with β-catenin and Armadillo to mediate Wnt/Wingless
signaling. We now report the characterization of genes encoding two murine members of the Tcf …