Mammalian fertilization comprises sperm migration through the female reproductive tract,
biochemical and morphological changes to sperm, and sperm-egg interaction in the oviduct. …

The green fluorescent protein (GFP) is responsible for the green bioluminescence of the
jellyfish Aequorea victoria. Many classes of GFP mutants exist that display modified …

A necrotic immature mandibular second premolar with periapical involvement in a 13‐year‐old
patient was treated. Instead of the standard root canal treatment protocol and …

Representing the 60 trillion cells that build a human body, a sperm and an egg meet,
recognize each other, and fuse to form a new generation of life. The factors involved in this …

The RNA-guided endonuclease Cas9 cleaves its target DNA and is a powerful genome-editing
tool. However, the widely used Streptococcus pyogenes Cas9 enzyme (SpCas9) …

Silencing of transposable elements occurs during fetal gametogenesis in males via de novo
DNA methylation of their regulatory regions. The loss of MILI (miwi-like) and MIWI2 (mouse …

The piwi family genes, which are defined by conserved PAZ and Piwi domains, play important
roles in stem cell self-renewal, RNA silencing, and translational regulation in various …

Neurofibrillary tangles, which consist of highly phosphorylated tau protein, and senile plaques
(SPs) are pathological hallmarks of Alzheimer’s disease (AD). In swollen axons, many …

… was measured spectrophotometrically at 383 µ in 0.1 M phosphate buffer,pH 6.8, where this
… Solutions containing serine (0.05 ), indole (0.05 M), pyridoxal (0.02 M) and alum (0.002 M) …

The introduction of foreign genes into early mouse embryos and embryonic stem (ES) cells
is invaluable for the analysis of gene function and regulation in the living animal. The use of …