Accumulating evidence suggests that a high tumour burden has a negative effect on anticancer
immunity. The concept of tumour burden, simply defined as the total amount of cancer in …

Obsessive–compulsive disorder (OCD) is a chronic and debilitating condition that is relatively
common in both children and adults, and it is associated with a wide range of functional …

A better and earlier identification of cancer-resistance mechanisms could avoid the use of
ineffective drugs in patients not responding to therapy and provide the rationale for the …

Background To date, no immunological data on COVID-19 heterologous vaccination schedules
in humans have been reported. We assessed the immunogenicity and reactogenicity of …

We describe a method for generating gene replacements and deletions in Escherichia coli.
The technique is simple and rapid and can be applied to most genes, even those that are …

A set of Saccharomyces cerevisiae expression vectors has been developed in which
transcription is driven by a hybrid tetO‐CYC1 promoter through the action of a tetR‐VP16 (tTA) …

This directory was made possible by a unique international collaboration between the 633
scientists whose names appear below. It represents both the first published description of the …

We have developed an activator/repressor expression system for budding yeast in which
tetracyclines control in opposite ways the ability of tetR-based activator and repressor …

Atherosclerosis is a complex process characterized by an increase in the wall thickness
owing to the accumulation of cells and extracellular matrix between the endothelium and the …

In this work, we identify co-occurring genomic alterations in KEAP1 , SMARCA4 , and CDKN2A
as independent determinants of poor clinical outcomes with KRAS G12Ci monotherapy …