Ecdysone Control of Developmental Transitions: Lessons from Drosophila Research

…, KF Rewitz, MB O'Connor - Annual review of …, 2013 - annualreviews.org
The steroid hormone ecdysone is the central regulator of insect developmental transitions.
Recent new advances in our understanding of ecdysone action have relied heavily on the …

Shaping BMP morphogen gradients in the Drosophila embryo and pupal wing

MB O'Connor, D Umulis, HG Othmer, SS Blair - 2006 - journals.biologists.com
In the early Drosophila embryo, BMP-type ligands act as morphogens to suppress neural
induction and to specify the formation of dorsal ectoderm and amnioserosa. Likewise, during …

The extracellular regulation of bone morphogenetic protein signaling

D Umulis, MB O'Connor, SS Blair - Development, 2009 - journals.biologists.com
In many cases, the level, positioning and timing of signaling through the bone morphogenetic
protein (BMP) pathway are regulated by molecules that bind BMP ligands in the …

[HTML][HTML] Histone methyltransferase activity of a Drosophila Polycomb group repressor complex

…, A Sengupta, B Wild, EL Miller, MB O'Connor… - Cell, 2002 - cell.com
Polycomb group (PcG) proteins maintain transcriptional repression during development,
likely by creating repressive chromatin states. The Extra Sex Combs (ESC) and Enhancer of …

[HTML][HTML] MADR1, a MAD-related protein that functions in BMP2 signaling pathways

…, T Haerry, S Abdollah, M Stapleton, MB O'Connor… - Cell, 1996 - cell.com
Components of the signaling pathways that lie downstream of Ser/Thr kinase receptors and
are required for signaling by the TGFβ superfamily have been poorly defined. The …

Shade is the Drosophila P450 enzyme that mediates the hydroxylation of ecdysone to the steroid insect molting hormone 20-hydroxyecdysone

…, C Dauphin-Villemant, MB O'Connor - Proceedings of the …, 2003 - National Acad Sciences
The steroid 20-hydroxyecdysone (20E) is the primary regulatory hormone that mediates
developmental transitions in insects and other arthropods. 20E is produced from ecdysone (E) …

[PDF][PDF] The BMP homolog Gbb provides a retrograde signal that regulates synaptic growth at the Drosophila neuromuscular junction

…, ML Crotty, TE Haerry, CS Goodman, MB O'Connor - Neuron, 2003 - cell.com
We show that the BMP ortholog Gbb can signal by a retrograde mechanism to regulate
synapse growth of the Drosophila neuromuscular junction (NMJ). gbb mutants have a reduced …

[PDF][PDF] Prothoracicotropic hormone regulates developmental timing and body size in Drosophila

…, C Dauphin-Villemant, LI Gilbert, MB O'Connor - Developmental cell, 2007 - cell.com
In insects, control of body size is intimately linked to nutritional quality as well as environmental
and genetic cues that regulate the timing of developmental transitions. Prothoracicotropic …

Molecular and biochemical characterization of two P450 enzymes in the ecdysteroidogenic pathway of Drosophila melanogaster

…, C Dauphin-Villemant, MB O'Connor… - Proceedings of the …, 2002 - National Acad Sciences
Five different enzymatic activities, catalyzed by both microsomal and mitochondrial cytochrome
P450 monooxygenases (CYPs), are strongly implicated in the biosynthesis of ecdysone (…

[PDF][PDF] The Drosophila BMP type II receptor Wishful Thinking regulates neuromuscular synapse morphology and function

…, MJ Shimell, P Duchek, B Zhang, MB O'Connor - Neuron, 2002 - cell.com
Proper synaptic development is critical for establishing all aspects of neural function including
learning, memory, and locomotion. Here, we describe the phenotypic consequences of …