Ecdysone Control of Developmental Transitions: Lessons from Drosophila Research
…, KF Rewitz, MB O'Connor - Annual review of …, 2013 - annualreviews.org
The steroid hormone ecdysone is the central regulator of insect developmental transitions.
Recent new advances in our understanding of ecdysone action have relied heavily on the …
Recent new advances in our understanding of ecdysone action have relied heavily on the …
Shaping BMP morphogen gradients in the Drosophila embryo and pupal wing
In the early Drosophila embryo, BMP-type ligands act as morphogens to suppress neural
induction and to specify the formation of dorsal ectoderm and amnioserosa. Likewise, during …
induction and to specify the formation of dorsal ectoderm and amnioserosa. Likewise, during …
The extracellular regulation of bone morphogenetic protein signaling
D Umulis, MB O'Connor, SS Blair - Development, 2009 - journals.biologists.com
In many cases, the level, positioning and timing of signaling through the bone morphogenetic
protein (BMP) pathway are regulated by molecules that bind BMP ligands in the …
protein (BMP) pathway are regulated by molecules that bind BMP ligands in the …
[HTML][HTML] Histone methyltransferase activity of a Drosophila Polycomb group repressor complex
…, A Sengupta, B Wild, EL Miller, MB O'Connor… - Cell, 2002 - cell.com
Polycomb group (PcG) proteins maintain transcriptional repression during development,
likely by creating repressive chromatin states. The Extra Sex Combs (ESC) and Enhancer of …
likely by creating repressive chromatin states. The Extra Sex Combs (ESC) and Enhancer of …
[HTML][HTML] MADR1, a MAD-related protein that functions in BMP2 signaling pathways
…, T Haerry, S Abdollah, M Stapleton, MB O'Connor… - Cell, 1996 - cell.com
Components of the signaling pathways that lie downstream of Ser/Thr kinase receptors and
are required for signaling by the TGFβ superfamily have been poorly defined. The …
are required for signaling by the TGFβ superfamily have been poorly defined. The …
Shade is the Drosophila P450 enzyme that mediates the hydroxylation of ecdysone to the steroid insect molting hormone 20-hydroxyecdysone
…, C Dauphin-Villemant, MB O'Connor - Proceedings of the …, 2003 - National Acad Sciences
The steroid 20-hydroxyecdysone (20E) is the primary regulatory hormone that mediates
developmental transitions in insects and other arthropods. 20E is produced from ecdysone (E) …
developmental transitions in insects and other arthropods. 20E is produced from ecdysone (E) …
[PDF][PDF] The BMP homolog Gbb provides a retrograde signal that regulates synaptic growth at the Drosophila neuromuscular junction
…, ML Crotty, TE Haerry, CS Goodman, MB O'Connor - Neuron, 2003 - cell.com
We show that the BMP ortholog Gbb can signal by a retrograde mechanism to regulate
synapse growth of the Drosophila neuromuscular junction (NMJ). gbb mutants have a reduced …
synapse growth of the Drosophila neuromuscular junction (NMJ). gbb mutants have a reduced …
[PDF][PDF] Prothoracicotropic hormone regulates developmental timing and body size in Drosophila
…, C Dauphin-Villemant, LI Gilbert, MB O'Connor - Developmental cell, 2007 - cell.com
In insects, control of body size is intimately linked to nutritional quality as well as environmental
and genetic cues that regulate the timing of developmental transitions. Prothoracicotropic …
and genetic cues that regulate the timing of developmental transitions. Prothoracicotropic …
Molecular and biochemical characterization of two P450 enzymes in the ecdysteroidogenic pathway of Drosophila melanogaster
…, C Dauphin-Villemant, MB O'Connor… - Proceedings of the …, 2002 - National Acad Sciences
Five different enzymatic activities, catalyzed by both microsomal and mitochondrial cytochrome
P450 monooxygenases (CYPs), are strongly implicated in the biosynthesis of ecdysone (…
P450 monooxygenases (CYPs), are strongly implicated in the biosynthesis of ecdysone (…
[PDF][PDF] The Drosophila BMP type II receptor Wishful Thinking regulates neuromuscular synapse morphology and function
…, MJ Shimell, P Duchek, B Zhang, MB O'Connor - Neuron, 2002 - cell.com
Proper synaptic development is critical for establishing all aspects of neural function including
learning, memory, and locomotion. Here, we describe the phenotypic consequences of …
learning, memory, and locomotion. Here, we describe the phenotypic consequences of …