Inflammasomes are molecular complexes that trigger an inflammatory response upon
detection of pathogens or danger signals. Recent studies suggest that they are also involved in …

NLRP3 is a pattern recognition receptor with a well-documented role in inducing inflammasome
assembly in response to cellular stress. Deregulation of its activity leads to many …

The DNA damage response (DDR) is essential to preserve genomic integrity and acts as a
barrier to cancer. The ATM pathway orchestrates the cellular response to DNA double strand …

CONCLUSION A different outcome in clinical utility for a specific context of use might be
caused by a possible interference of Aβ isoforms with a free Aβ1 terminus in the Aβ (1-42) …

Background Cerebrospinal Fluid (CSF) proteins Amyloid Beta 1-42 (Aβ 42), total-tau and p-tau
181 directly reflect the core hallmarks of Alzheimer's Disease and can be detected prior to …

Background Accumulation of amyloid-β (Aβ) into plaques in the brain is one of the hallmarks
of Alzheimer's Disease (AD). This neurotoxic peptide is produced by the consecutive …

Background α-Synuclein is a pre-synaptic protein whose abnormal aggregation is the main
characteristic of a sub-group of neurodegenerative disorders called α-synucleinopathies, …

… M Bodnar-Wachtel was supported by the ANRT, V Petrilli by the plan Cancer, Ligue
Contre le Cancer Comité de l’Ain, the ARC foundation, and the Fondation pour la Recherche …

Background Sporadic Alzheimer disease (AD) is the most common form of AD, yet its causes
are currently unknown. Several studies have indicated that abnormal levels of electrolytes …

Background Obesity at mid-life is a major risk factor for developing dementia; this may be, at
least in part, due to vascular dysfunction. Studies done in dementia cohorts showed the …