[HTML][HTML] Pharmacological disruption of mSWI/SNF complex activity restricts SARS-CoV-2 infection
…, R Rosales, BL McGovern, M Luis Rodriguez… - Nature Genetics, 2023 - nature.com
Identification of host determinants of coronavirus infection informs mechanisms of viral
pathogenesis and can provide new drug targets. Here we demonstrate that mammalian SWItch/…
pathogenesis and can provide new drug targets. Here we demonstrate that mammalian SWItch/…
Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19
…, BL McGovern, ML Rodriguez… - Life science …, 2022 - life-science-alliance.org
Plitidepsin, a marine-derived cyclic-peptide, inhibits SARS-CoV-2 replication at nanomolar
concentrations by targeting the host protein eukaryotic translation elongation factor 1A. Here, …
concentrations by targeting the host protein eukaryotic translation elongation factor 1A. Here, …
Nirmatrelvir, Molnupiravir, and Remdesivir maintain potent in vitro activity against the SARS-CoV-2 Omicron variant
Variants of SARS-CoV-2 have become a major public health concern due to increased
transmissibility, and escape from natural immunity, vaccine protection, and monoclonal antibody …
transmissibility, and escape from natural immunity, vaccine protection, and monoclonal antibody …
[HTML][HTML] Epitope spreading driven by the joint action of CART cells and pharmacological STING stimulation counteracts tumor escape via antigen-loss variants
…, E Rodríguez-García, M Hommel… - … for ImmunoTherapy of …, 2021 - ncbi.nlm.nih.gov
Background Target antigen (Ag) loss has emerged as a major cause of relapse after chimeric
antigen receptor T (CART)-cell therapy. We reasoned that the combination of CART cells, …
antigen receptor T (CART)-cell therapy. We reasoned that the combination of CART cells, …
Global landscape of the host response to SARS-CoV-2 variants reveals viral evolutionary trajectories
…, D Mesner, JL Turner, BL McGovern, ML Rodriguez… - bioRxiv, 2022 - biorxiv.org
A series of SARS-CoV-2 variants of concern (VOCs) have evolved in humans during the
COVID-19 pandemic—Alpha, Beta, Gamma, Delta, and Omicron. Here, we used global …
COVID-19 pandemic—Alpha, Beta, Gamma, Delta, and Omicron. Here, we used global …
[HTML][HTML] Successful kinetic impact into an asteroid for planetary defence
…, EL Reynolds, JE Richman, CQ Robin, LM Rodriguez… - Nature, 2023 - nature.com
Although no known asteroid poses a threat to Earth for at least the next century, the catalogue
of near-Earth asteroids is incomplete for objects whose impacts would produce regional …
of near-Earth asteroids is incomplete for objects whose impacts would produce regional …
Structure–mechanical property correlations of hydrogel forming β-sheet peptides
Peptide based hydrogels have received much attention due to their potential biomedical
applications. The majority of the gel forming peptides present a β-sheet motif that is composed …
applications. The majority of the gel forming peptides present a β-sheet motif that is composed …
Monitoring of COVID-19 patients via telemedicine with telemonitoring
…, R Suárez-Gil, A Rodríguez-Álvarez… - Revista Clínica …, 2020 - Elsevier
Aim To asses if telemedicine with telemonitoring is a clinically useful and safe tool for
monitoring patients with COVID-19. Methods A prospective observational study of patients with …
monitoring patients with COVID-19. Methods A prospective observational study of patients with …
Testing non-linearity and directedness of interactions between neural groups in the macaque inferotemporal cortex
…, JC Jimenez, LM Rodriguez, V Rodriguez… - Journal of neuroscience …, 1999 - Elsevier
Information processing in the visual cortex depends on complex and context sensitive patterns
of interactions between neuronal groups in many different cortical areas. Methods used to …
of interactions between neuronal groups in many different cortical areas. Methods used to …
[HTML][HTML] High throughput ANI analysis of 90K prokaryotic genomes reveals clear species boundaries
A fundamental question in microbiology is whether there is continuum of genetic diversity
among genomes, or clear species boundaries prevail instead. Whole-genome similarity …
among genomes, or clear species boundaries prevail instead. Whole-genome similarity …