User profiles for Lucia Fernandez-del-Rio

Lucia Fernandez-del-Rio

UCLA
Verified email at g.ucla.edu
Cited by 650

[HTML][HTML] Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease

…, A Petcherski, L Fernández-del-Rio… - Nature …, 2023 - nature.com
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the world.
High levels of free fatty acids in the liver impair hepatic lysosomal acidification and reduce …

Coenzyme Q10 deficiencies: pathways in yeast and humans

AM Awad, MC Bradley… - Essays in …, 2018 - portlandpress.com
Coenzyme Q (ubiquinone or CoQ) is an essential lipid that plays a role in mitochondrial
respiratory electron transport and serves as an important antioxidant. In human and yeast cells, …

[HTML][HTML] Coenzyme Q biosynthesis: an update on the origins of the benzenoid ring and discovery of new ring precursors

L Fernández-del-Río, CF Clarke - Metabolites, 2021 - mdpi.com
Coenzyme Q (ubiquinone or CoQ) is a conserved polyprenylated lipid essential for
mitochondrial respiration. CoQ is composed of a redox-active benzoquinone ring and a long …

Ubiquinol effects on antiphospholipid syndrome prothrombotic profile: a randomized, placebo-controlled trial

C Pérez-Sánchez, MÁ Aguirre… - … , and vascular biology, 2017 - Am Heart Assoc
Objective— Antiphospholipid syndrome (APS) leukocytes exhibit an oxidative perturbation,
directly linked to alterations in mitochondrial dynamics and metabolism. This disturbance is …

Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies

R Acin‐Perez, C Benincá, L Fernandez del Rio… - The EMBO …, 2023 - embopress.org
The maintenance of cellular function relies on the close regulation of adenosine triphosphate
(ATP) synthesis and hydrolysis. ATP hydrolysis by mitochondrial ATP Synthase (CV) is …

[PDF][PDF] The mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism

MG Acoba, ESS Alpergin, S Renuse… - Cell reports, 2021 - cell.com
Mitochondrial carriers (MCs) mediate the passage of small molecules across the inner
mitochondrial membrane (IMM), enabling regulated crosstalk between compartmentalized …

ADCK4 deficiency destabilizes the coenzyme Q complex, which is rescued by 2, 4-dihydroxybenzoic acid treatment

E Widmeier, S Yu, A Nag, YW Chung… - Journal of the …, 2020 - journals.lww.com
Background Mutations in ADCK4 (aarF domain containing kinase 4) generally manifest as
steroid-resistant nephrotic syndrome and induce coenzyme Q 10 (CoQ 10) deficiency. …

The endoplasmic reticulum-mitochondria encounter structure complex coordinates coenzyme Q biosynthesis

M Eisenberg-Bord, HS Tsui, D Antunes… - …, 2019 - journals.sagepub.com
Loss of the endoplasmic reticulum (ER)-mitochondria encounter structure (ERMES) complex
that resides in contact sites between the yeast ER and mitochondria leads to impaired …

Kaempferol increases levels of coenzyme Q in kidney cells and serves as a biosynthetic ring precursor

L Fernández-del-Río, A Nag, EG Casado… - Free Radical Biology …, 2017 - Elsevier
Coenzyme Q (Q) is a lipid-soluble antioxidant essential in cellular physiology. Patients with
Q deficiencies, with few exceptions, seldom respond to treatment. Current therapies rely on …

[HTML][HTML] Olive oil and the hallmarks of aging

L Fernandez del Rio, E Gutiérrez-Casado… - Molecules, 2016 - mdpi.com
Aging is a multifactorial and tissue-specific process involving diverse alterations regarded
as the “hallmarks of aging”, which include genomic instability, telomere attrition, epigenetic …