User profiles for Lucia Fernandez-del-Rio
Lucia Fernandez-del-RioUCLA Verified email at g.ucla.edu Cited by 650 |
[HTML][HTML] Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease
…, A Petcherski, L Fernández-del-Rio… - Nature …, 2023 - nature.com
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the world.
High levels of free fatty acids in the liver impair hepatic lysosomal acidification and reduce …
High levels of free fatty acids in the liver impair hepatic lysosomal acidification and reduce …
Coenzyme Q10 deficiencies: pathways in yeast and humans
AM Awad, MC Bradley… - Essays in …, 2018 - portlandpress.com
Coenzyme Q (ubiquinone or CoQ) is an essential lipid that plays a role in mitochondrial
respiratory electron transport and serves as an important antioxidant. In human and yeast cells, …
respiratory electron transport and serves as an important antioxidant. In human and yeast cells, …
[HTML][HTML] Coenzyme Q biosynthesis: an update on the origins of the benzenoid ring and discovery of new ring precursors
L Fernández-del-Río, CF Clarke - Metabolites, 2021 - mdpi.com
Coenzyme Q (ubiquinone or CoQ) is a conserved polyprenylated lipid essential for
mitochondrial respiration. CoQ is composed of a redox-active benzoquinone ring and a long …
mitochondrial respiration. CoQ is composed of a redox-active benzoquinone ring and a long …
Ubiquinol effects on antiphospholipid syndrome prothrombotic profile: a randomized, placebo-controlled trial
C Pérez-Sánchez, MÁ Aguirre… - … , and vascular biology, 2017 - Am Heart Assoc
Objective— Antiphospholipid syndrome (APS) leukocytes exhibit an oxidative perturbation,
directly linked to alterations in mitochondrial dynamics and metabolism. This disturbance is …
directly linked to alterations in mitochondrial dynamics and metabolism. This disturbance is …
Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies
R Acin‐Perez, C Benincá, L Fernandez del Rio… - The EMBO …, 2023 - embopress.org
The maintenance of cellular function relies on the close regulation of adenosine triphosphate
(ATP) synthesis and hydrolysis. ATP hydrolysis by mitochondrial ATP Synthase (CV) is …
(ATP) synthesis and hydrolysis. ATP hydrolysis by mitochondrial ATP Synthase (CV) is …
[PDF][PDF] The mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism
Mitochondrial carriers (MCs) mediate the passage of small molecules across the inner
mitochondrial membrane (IMM), enabling regulated crosstalk between compartmentalized …
mitochondrial membrane (IMM), enabling regulated crosstalk between compartmentalized …
ADCK4 deficiency destabilizes the coenzyme Q complex, which is rescued by 2, 4-dihydroxybenzoic acid treatment
Background Mutations in ADCK4 (aarF domain containing kinase 4) generally manifest as
steroid-resistant nephrotic syndrome and induce coenzyme Q 10 (CoQ 10) deficiency. …
steroid-resistant nephrotic syndrome and induce coenzyme Q 10 (CoQ 10) deficiency. …
The endoplasmic reticulum-mitochondria encounter structure complex coordinates coenzyme Q biosynthesis
M Eisenberg-Bord, HS Tsui, D Antunes… - …, 2019 - journals.sagepub.com
Loss of the endoplasmic reticulum (ER)-mitochondria encounter structure (ERMES) complex
that resides in contact sites between the yeast ER and mitochondria leads to impaired …
that resides in contact sites between the yeast ER and mitochondria leads to impaired …
Kaempferol increases levels of coenzyme Q in kidney cells and serves as a biosynthetic ring precursor
L Fernández-del-Río, A Nag, EG Casado… - Free Radical Biology …, 2017 - Elsevier
Coenzyme Q (Q) is a lipid-soluble antioxidant essential in cellular physiology. Patients with
Q deficiencies, with few exceptions, seldom respond to treatment. Current therapies rely on …
Q deficiencies, with few exceptions, seldom respond to treatment. Current therapies rely on …
[HTML][HTML] Olive oil and the hallmarks of aging
L Fernandez del Rio, E Gutiérrez-Casado… - Molecules, 2016 - mdpi.com
Aging is a multifactorial and tissue-specific process involving diverse alterations regarded
as the “hallmarks of aging”, which include genomic instability, telomere attrition, epigenetic …
as the “hallmarks of aging”, which include genomic instability, telomere attrition, epigenetic …