User profiles for Lucía Chávez-Gutiérrez

Lucía Chávez-Gutiérrez

University of Leuven / VIB Center for Brain & Disease Research
Verified email at kuleuven.vib.be
Cited by 3329

Qualitative changes in human γ-secretase underlie familial Alzheimer's disease

…, H Gijsen, B De Strooper, L Chávez-Gutiérrez - Journal of Experimental …, 2015 - rupress.org
Presenilin (PSEN) pathogenic mutations cause familial Alzheimer’s disease (AD [FAD]) in
an autosomal-dominant manner. The extent to which the healthy and diseased alleles …

[HTML][HTML] Aβ profiles generated by Alzheimer's disease causing PSEN1 variants determine the pathogenicity of the mutation and predict age at disease onset

…, R Vandenberghe, NC Fox, L Chávez-Gutiérrez - Molecular …, 2022 - nature.com
Familial Alzheimer’s disease (FAD), caused by mutations in Presenilin (PSEN1/2) and
Amyloid Precursor Protein (APP) genes, is associated with an early age at onset (AAO) of …

The mechanism of γ‐secretase dysfunction in familial Alzheimer disease

L ChávezGutiérrez, L Bammens, I Benilova… - The EMBO …, 2012 - embopress.org
The mechanisms by which mutations in the presenilins (PSEN) or the amyloid precursor
protein (APP) genes cause familial Alzheimer disease (FAD) are controversial. FAD mutations …

Learning by failing: ideas and concepts to tackle γ-secretases in Alzheimer's disease and beyond

…, L Chávez Gutiérrez - Annual review of …, 2015 - annualreviews.org
γ-Secretases are a group of widely expressed, intramembrane-cleaving proteases involved
in many physiological processes. Their clinical relevance comes from their involvement in …

[HTML][HTML] Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the γ-secretase complex

A Tolia, L Chávez-Gutiérrez, B De Strooper - Journal of Biological …, 2006 - ASBMB
γ-Secretase is a multiprotein complex responsible for the intramembranous cleavage of the
amyloid precursor protein and other type I transmembrane proteins. Mutations in Presenilin, …

[HTML][HTML] Glu332 in the nicastrin ectodomain is essential for γ-secretase complex maturation but not for its activity

L Chávez-Gutiérrez, A Tolia, E Maes, T Li… - Journal of biological …, 2008 - ASBMB
The γ-secretase complex is responsible for the proteolysis of integral membrane proteins.
Nicastrin has been proposed to operate as the substrate receptor of the complex with the …

[PDF][PDF] LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis

…, D Haddad, L Delbroek, J Swerts, L Chávez-Gutiérrez… - Neuron, 2012 - cell.com
LRRK2 is a kinase mutated in Parkinson's disease, but how the protein affects synaptic
function remains enigmatic. We identified LRRK2 as a critical regulator of EndophilinA. Using …

[HTML][HTML] Signature amyloid β profiles are produced by different γ-secretase complexes

H Acx, L Chávez-Gutiérrez, L Serneels… - Journal of Biological …, 2014 - ASBMB
γ-Secretase complexes are involved in the generation of amyloid-β (Aβ) in the brain. Therefore,
γ-secretase has been proposed as a potential therapeutic target in Alzheimer disease (…

[PDF][PDF] Alzheimer's-causing mutations shift Aβ length by destabilizing γ-secretase-Aβn interactions

…, NC Fox, C Hopf, B De Strooper, L Chávez-Gutiérrez - Cell, 2017 - cell.com
Alzheimer's disease (AD)-linked mutations in Presenilins (PSEN) and the amyloid precursor
protein (APP) lead to production of longer amyloidogenic Aβ peptides. The shift in Aβ length …

Modification of γ‐secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease

…, A Snellinx, L ChávezGutiérrez… - EMBO molecular …, 2012 - embopress.org
Inherited familial Alzheimer's disease (AD) is characterized by small increases in the ratio of
Aβ42 versus Aβ40 peptide which is thought to drive the amyloid plaque formation in the …