Mechanism of activation of the TGF-β receptor
Transforming growth factor-β (TGF-β) signals by contacting two distantly related transmem-brane
serine/threonine kinases called receptors I and II. The role of these molecules in …
serine/threonine kinases called receptors I and II. The role of these molecules in …
The TGFbeta superfamily signaling pathway
A Weiss, L Attisano - Wiley Interdisciplinary Reviews …, 2013 - Wiley Online Library
The transforming growth factor (TGF)beta superfamily of secreted factors is comprised of over
30 members including Activins, Nodals, Bone Morphogenetic Proteins (BMPs), and Growth …
30 members including Activins, Nodals, Bone Morphogenetic Proteins (BMPs), and Growth …
TGFβ signals through a heteromeric protein kinase receptor complex
Transforming growth factor p (TGFfl) binds with high affinity to the type II receptor, a transmembrane
protein with a cytoplasmic serine/threonine kinase domain. We show that the type II …
protein with a cytoplasmic serine/threonine kinase domain. We show that the type II …
Signal transduction by the TGF-β superfamily
L Attisano, JL Wrana - Science, 2002 - science.org
Transforming growth factor–β (TGF-β) superfamily members regulate a plethora of developmental
processes, and disruption of their activity has been implicated in a variety of human …
processes, and disruption of their activity has been implicated in a variety of human …
[HTML][HTML] SARA, a FYVE domain protein that recruits Smad2 to the TGFβ receptor
T Tsukazaki, TA Chiang, AF Davison, L Attisano… - Cell, 1998 - cell.com
Smads transmit signals from transmembrane ser/thr kinase receptors to the nucleus. We
now identify SARA (for S mad a nchor for r eceptor a ctivation), a FYVE domain protein that …
now identify SARA (for S mad a nchor for r eceptor a ctivation), a FYVE domain protein that …
[HTML][HTML] MADR2 maps to 18q21 and encodes a TGFβ–regulated MAD–related protein that is functionally mutated in colorectal carcinoma
…, IL Andrulis, GH Thomsen, JL Wrana, L Attisano - Cell, 1996 - cell.com
The MAD–related (MADR) family of proteins are essential components in the signaling
pathways of serine/threonine kinase receptors for the transforming growth factor β (TGFβ) …
pathways of serine/threonine kinase receptors for the transforming growth factor β (TGFβ) …
[HTML][HTML] MADR2 is a substrate of the TGFβ receptor and its phosphorylation is required for nuclear accumulation and signaling
…, S Abdollah, PA Hoodless, R Pirone, L Attisano… - Cell, 1996 - cell.com
MAD-related (MADR) proteins are essential intracellular components of TGFβ signaling
pathways and are regulated by phosphorylation. Here, we demonstrate that MADR2 and not the …
pathways and are regulated by phosphorylation. Here, we demonstrate that MADR2 and not the …
Identification of human activin and TGFβ type I receptors that form heteromeric kinase complexes with type II receptors
L Attisano, J Cárcamo, F Ventura, FMB Weis… - Cell, 1993 - cell.com
Transforming growth factor p (TGFf3) and activin each bind to pairs of membrane proteins,
known as receptor types I and II, that associate to form a signaling complex. We report that …
known as receptor types I and II, that associate to form a signaling complex. We report that …
[HTML][HTML] MADR1, a MAD-related protein that functions in BMP2 signaling pathways
…, S Abdollah, M Stapleton, MB O'Connor, L Attisano… - Cell, 1996 - cell.com
Components of the signaling pathways that lie downstream of Ser/Thr kinase receptors and
are required for signaling by the TGFβ superfamily have been poorly defined. The …
are required for signaling by the TGFβ superfamily have been poorly defined. The …
[HTML][HTML] TβRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling
…, T Tsukazaki, H Hayashi, L Attisano… - Journal of Biological …, 1997 - ASBMB
Mothers against Dpp-related or Smad proteins are essential components of serine/threonine
kinase receptor signaling pathways that are regulated by phosphorylation. Recently, it was …
kinase receptor signaling pathways that are regulated by phosphorylation. Recently, it was …