The human kidney is composed of roughly 1.2-million renal tubules that must maintain their
tubular structure to function properly. In autosomal dominant polycystic kidney disease (…

ANGIOGENESIS, the formation of new microvasculature by capillary sprouting, is crucial for
tumour development 1 . Hypoxic regions of solid tumours produce the powerful and directly …

PKD1 and PKD2 are two recently identified genes that are responsible for the vast majority of
autosomal polycystic kidney disease, a common inherited disease that causes progressive …

Angiogenesis, the development of new capillaries, is tightly controlled by the balance of
positive and negative regulatory pathways. A newly described angiogenic factor, vascular …

The function(s) of the genes (PKD1 and PKD2) responsible for the majority of cases of autosomal
dominant polycystic kidney disease is unknown. While PKD1 encodes a large integral …

Rationale: Cardiac muscle adapts to increase workload by altering cardiomyocyte size and
function resulting in cardiac hypertrophy. G protein–coupled receptor signaling is known to …

Endostatin, a collagen XVIII fragment, is a potent anti-angiogenic protein. We sought to identify
its endothelial cell surface receptor(s). Alkaline phosphatase– tagged endostatin bound …

The primary cilium is an antenna-like organelle that is dynamically regulated during the cell
cycle. Ciliogenesis is initiated as cells enter quiescence, whereas resorption of the cilium …

Signaling through the store-operated Ca 2+ release-activated Ca 2+ (CRAC) channel regulates
critical cellular functions, including gene expression, cell growth and differentiation, and …

PKD2, or polycystin 2, the product of the gene mutated in type 2 autosomal dominant polycystic
kidney disease, belongs to the transient receptor potential channel superfamily and has …