Among emerging biomaterials, bioactive glasses (BGs) are being widely explored for
various applications in tissue engineering. However, the effects of BGs (in particular BG ionic …

Excessive macrophage (Mφ) activation results in chronic inflammatory responses or
autoimmune diseases. Therefore, identification of novel immune checkpoints on Mφ, which …

Purpose Limbal melanocytes (LMel) represent essential components of the corneal
epithelial stem cell niche and are known to protect limbal epithelial stem/progenitor cells (LEPCs) …

Foxp3-positive regulatory T cells (Tregs) are crucial for the maintenance of immune homeostasis
and keep immune responses in check. Upon activation, Tregs are transferred into an …

The aryl hydrocarbon receptor (AhR) is an environmental sensor and ligand-activated
transcription factor that is critically involved in the regulation of inflammatory responses and the …

Dendritic cells (DCs) are crucial to balance protective immunity and autoimmune inflammatory
processes. Expression of CD83 is a well-established marker for mature DCs, although its …

Background Plasma extracellular vesicles (pEV) can harbor a diverse array of factors including
active proteases and the amyloid-precursor-protein (APP) cleavage product Aβ, involved …

To facilitate the recovery process of chronic and hard-to-heal wounds novel pro-resolving
treatment options are urgently needed. We investigated the pro-regenerative properties of …

During inflammation, murine and human monocytes can develop into dendritic cells (DC),
but this process is not entirely understood. Here, we demonstrate that extracellular vesicles (…

Interference with autoimmune-mediated cytokine production is a key yet poorly developed
approach to treat autoimmune and inflammatory diseases such as rheumatoid arthritis. Herein…