[HTML][HTML] Human brain organoids as models for central nervous system viral infection

JA Depla, LA Mulder, RV de Sá, M Wartel, A Sridhar… - Viruses, 2022 - mdpi.com
Pathogenesis of viral infections of the central nervous system (CNS) is poorly understood,
and this is partly due to the limitations of currently used preclinical models. Brain organoid …

Enterovirus D68 infection in human primary airway and brain organoids: No additional role for heparan sulfate binding for neurotropism

A Sridhar, JA Depla, LA Mulder, E Karelehto… - Microbiology …, 2022 - Am Soc Microbiol
Enterovirus D68 (EV-D68) is an RNA virus that can cause outbreaks of acute flaccid paralysis
(AFP), a polio-like disease. Before 2010, EV-D68 was a rare pathogen associated with …

[HTML][HTML] A beginner's guide on the use of brain organoids for neuroscientists: a systematic review

LA Mulder, JA Depla, A Sridhar, K Wolthers… - Stem cell research & …, 2023 - Springer
Background The first human brain organoid protocol was presented in the beginning of the
previous decade, and since then, the field witnessed the development of many new brain …

[HTML][HTML] Cerebral organoids: a human model for AAV capsid selection and therapeutic transgene efficacy in the brain

JA Depla, M Sogorb-Gonzalez, LA Mulder… - … Therapy Methods & …, 2020 - cell.com
The development of gene therapies for central nervous system disorders is challenging
because it is difficult to translate preclinical data from current in vitro and in vivo models to the …

[HTML][HTML] Parechovirus infection in human brain organoids: host innate inflammatory response and not neuro-infectivity correlates to neurologic disease

…, I García-Rodríguez, AT Ambikan, LA Mulder… - Nature …, 2024 - nature.com
Picornaviruses are a leading cause of central nervous system (CNS) infections. While
genotypes such as parechovirus A3 (PeV-A3) and echovirus 11 (E11) can elicit severe …

Human milk inhibits some enveloped virus infections, including SARS-CoV-2, in an intestinal model

…, C Calitz, I García-Rodríguez, L Mulder… - Life Science …, 2022 - life-science-alliance.org
Human milk is important for antimicrobial defense in infants and has well demonstrated
antiviral activity. We evaluated the protective ability of human milk against severe acute …

[HTML][HTML] Assessment of the broad-spectrum host targeting antiviral efficacy of halofuginone hydrobromide in human airway, intestinal and brain organotypic models.

…, G Moreni, PE Capendale, L Mulder… - Antiviral Research, 2024 - Elsevier
Halofuginone hydrobromide has shown potent antiviral efficacy against a variety of viruses
such as SARS-CoV-2, dengue, or chikungunya virus, and has, therefore, been hypothesized …

[PDF][PDF] A beginner's guide on the use of brain organoids for neuroscientists: a systematic

LA Mulder, JA Depla, A Sridhar, K Wolthers… - 2023 - stemcellres.biomedcentral.com
Background The first human brain organoid protocol was presented in the beginning of the
previous decade, and since then, the field witnessed the development of many new brain …

Parechovirus infections in human brain organoids: host immune response and not neuro-infectivity as a correlate of neuropathology

P Capendale, I García-Rodríguez, L Mulder, J Depla… - 2023 - researchsquare.com
Parechovirus A (PeV-A) is a species in the Picornaviridae family that can cause a variety of
diseases, mainly in children. The most prevalent genotype, PeV-A1, can causes mild …

[PDF][PDF] ECMO and anticoagulation: a comprehensive review

MMG Mulder, I Fawzy, MD Lancé - Neth J Crit Care, 2018 - researchgate.net
Since the last decade extracorporeal membrane oxygenation (ECMO) therapy has been
widely accepted as the treatment of life-threatening cardiac and pulmonary failure. Maintaining …