The culmination of decades of research on humanized mice is leading to advances in our
understanding of human haematopoiesis, innate and adaptive immunity, autoimmunity, …

Significant advances in our understanding of the in vivo functions of human cells and tissues
and the human immune system have resulted from the development of 'humanized' mouse …

Immunodeficient mice engrafted with functional human cells and tissues, that is, humanized
mice, have become increasingly important as small, preclinical animal models for the study …

The study of human hematopoietic cells and the human immune system is hampered by the
lack of a suitable experimental model. Experimental data are presented showing that human …

MICE homozygous for the recessive mutation osteopetrosis (op) on chromosome 3 have a
restricted capacity for bone remodelling, and are severely deficient in mature macrophages …

Ethical considerations constrain the in vivo study of human hemopoietic stem cells (HSC). To
overcome this limitation, small animal models of human HSC engraftment have been used. …

… The development of the C57BW6Sz-scid genetic stock and its phenotype will be reported
elsewhere (LD Shultz, manuscript in preparation). Figure 5B shows the heightened …

Acute myelogenous leukemia (AML) is the most common adult leukemia, characterized by
the clonal expansion of immature myeloblasts initiating from rare leukemic stem (LS) cells 1 , …

Here we report that a new nonobese diabetic/severe combined immunodeficient (NOD/SCID)
mouse line harboring a complete null mutation of the common cytokine receptor γ chain (…

Mice homozygous for the recessive allellc mutation motheaten (me) or viable motheaten (me’)
on chromosome 6 develop severe defects in hematopoiesis. In this paper we present the …