Tumors are complex cellular and acellular environments within which cancer clones are under
continuous selection pressures. Cancer cells are in a permanent mode of interaction and …

The introduction of large language models (LLMs) that allow iterative “chat” in late 2022 is a
paradigm shift that enables generation of text often indistinguishable from that written by …

Histone acetylation plays important roles in gene regulation, DNA replication, and the response
to DNA damage, and it is frequently deregulated in tumors. We postulated that tumor cell …

Autophagy is a highly conserved self-digestion process, which is essential for maintaining
homeostasis and viability in response to nutrient starvation 1 , 2 , 3 , 4 . Although the …

Prdm16 is a transcription factor that regulates the thermogenic gene program in brown and
beige adipocytes. However, whether Prdm16 is required for the development or …

The master transcription factor Pparγ regulates the general differentiation program of both
brown and white adipocytes. However, it has been unclear whether Pparγ also controls fat …

Human pancreatic islets consist of multiple endocrine cell types. To facilitate the detection of
rare cellular states and uncover population heterogeneity, we performed single-cell RNA …

Type 2 diabetes mellitus (T2DM) is a complex disease characterized by the inability of the
insulin-producing β cells in the endocrine pancreas to overcome insulin resistance in …

Obesity is characterized by an accumulation of macrophages in adipose, some of which form
distinct crown-like structures (CLS) around fat cells. While multiple discrete adipose tissue …

The majority of human cancers evolve over time through the stepwise accumulation of
somatic mutations followed by clonal selection akin to Darwinian evolution. However, the in-depth …