Heterozygous loss-of-function (LOF) mutations in PIK3R1 (encoding phosphatidylinositol 3-kinase
[PI3K] regulatory subunits) cause activated PI3Kδ syndrome 2 (APDS2), which has a …

Skeletal muscle and adipose tissue insulin resistance are major drivers of metabolic disease.
To uncover pathways involved in insulin resistance, specifically in these tissues, we …

The phosphoinositide 3-kinase (PI3K)-Akt network is tightly controlled by feedback
mechanisms that regulate signal flow and ensure signal fidelity. A rapid overshoot in insulin-…

Adipose tissue is essential for whole-body glucose homeostasis, with a primary role in lipid
storage. It has been previously observed that lactate production is also an important …

Exercise stimulates cellular and physiological adaptations that are associated with widespread
health benefits. To uncover conserved protein phosphorylation events underlying this …

Adipose tissue is essential for metabolic homeostasis, balancing lipid storage and mobilization
based on nutritional status. This is coordinated by insulin, which triggers kinase signaling …

The failure of metabolic tissues to appropriately respond to insulin (“insulin resistance”) is
an early marker in the pathogenesis of type 2 diabetes. Protein phosphorylation is central to …

Intermittent fasting is a beneficial dietary treatment for obesity. But the response of each distinct
adipose depot is currently poorly defined. Here we explore the response of key adipose …

Exercise engages signaling networks to control the release of circulating factors beneficial
to health. However, the nature of these networks remains undefined. Using high-throughput …

The Ser/Thr protein kinase Akt regulates essential biological processes such as cell survival,
growth, and metabolism. Upon growth factor stimulation, Akt is phosphorylated at Ser 474 ; …