Purpose: Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease characterized by an
extensive fibroinflammatory stroma, which includes abundant cancer-associated fibroblast …

Here, we describe an unexpected cross-talk between Tregs and fibroblasts in pancreatic
cancer. Treg depletion resulted in differentiation of inflammatory fibroblast subsets, in turn …

Pancreatic ductal adenocarcinoma (PDA) is a lethal disease notoriously resistant to therapy
1 , 2 . This is mediated in part by a complex tumour microenvironment 3 , low vascularity 4 , …

This study shows that elevated apolipoprotein E in PDAC mediates immune suppression
and high serum apolipoprotein E levels correlate with poor patient survival. See related …

Pancreatic ductal adenocarcinoma (PDA) is accompanied by reprogramming of the local
microenvironment, but changes at distal sites are poorly understood. We implanted biomaterial …

Pancreatic ductal adenocarcinoma (PDA) is associated with activation of WNT signaling.
Whether this signaling pathway regulates the tumor microenvironment has remained …

An extensive fibroinflammatory stroma rich in macrophages is a hallmark of pancreatic
cancer. In this disease, it is well appreciated that macrophages are immunosuppressive and …

Background & Aims Oncogenic Kirsten Rat Sarcoma virus (KRAS) is the hallmark mutation
of human pancreatic cancer and a driver of tumorigenesis in genetically engineered mouse …

Purpose: Pancreatic ductal adenocarcinoma (PDAC) is generally divided in two subtypes,
classical and basal. Recently, single cell RNA sequencing has uncovered the co-existence of …

Pancreatic ductal adenocarcinoma (PDA) continues to have a dismal prognosis. The poor
survival of patients with PDA has been attributed to a high rate of early metastasis and low …