Cyclase-associated proteins are highly conserved proteins that have a role in the regulation
of actin dynamics. Higher eukaryotes have two isoforms, CAP1 and CAP2. To study the in …

… Pandey2, Ruby Guo2, Taylor A Covington2, Venkata Thulabandu2, Kosmas Kosmas1,
Benjamin …

Cyclase associated protein (CAP) is a highly conserved protein with roles in actin dynamics
and many cellular processes. Two isoforms exist in higher eukaryotes, CAP1 and CAP2. …

Actin remodeling is crucial for dendritic spine development, morphology and density. CAP2
is a regulator of actin dynamics through sequestering G-actin and severing F-actin. In a …

This study demonstrates that TSC2 physically interacts with HDLBP/vigilin, a component of
SGs, that TSC2 localizes to SG and that TSC2-deficient cells have more SGs, suggesting that …

Vascular remodeling is the process of structural alteration and cell rearrangement of blood
vessels in response to injury and is the cause of many of the world’s most afflicted …

Pulmonary arterial hypertension (PAH) is a serious, progressive, and often fatal disease that
is in urgent need of improved therapies that treat it. One of the remaining therapeutic …

This study identifies macropinocytosis and phospholipid metabolism as novel mechanisms
of metabolic homeostasis in mTORC1-hyperactive cells and suggest ritanserin as a novel …

Background: Right ventricular (RV) performance is a key determinant of mortality in pulmonary
arterial hypertension (PAH). RV failure is characterized by metabolic dysregulation with …

Lymphangioleiomyomatosis (LAM) is a rare progressive disease, characterized by
mutations in the tuberous sclerosis complex genes (TSC1 or TSC2) and hyperactivation of …