Vnn1 pantetheinase limits the Warburg effect and sarcoma growth by rescuing mitochondrial activity
C Giessner, V Millet, KJ Mostert… - Life Science …, 2018 - life-science-alliance.org
Like other tumors, aggressive soft tissue sarcomas (STS) use glycolysis rather than mitochondrial
oxidative phosphorylation (OXPHOS) for growth. Given the importance of the cofactor …
oxidative phosphorylation (OXPHOS) for growth. Given the importance of the cofactor …
Developing pantetheinase-resistant pantothenamide antibacterials: structural modification impacts on PanK interaction and mode of action
L Barnard, KJ Mostert, WAL van Otterlo… - ACS Infectious …, 2018 - ACS Publications
Pantothenamides (PanAms) are analogues of pantothenate, the biosynthetic precursor of
coenzyme A (CoA), and show potent antimicrobial activity against several bacteria and the …
coenzyme A (CoA), and show potent antimicrobial activity against several bacteria and the …
The coenzyme A level modulator hopantenate (HoPan) inhibits phosphopantotenoylcysteine synthetase activity
KJ Mostert, N Sharma, M Van Der Zwaag… - ACS chemical …, 2021 - ACS Publications
The pantothenate analogue hopantenate (HoPan) is widely used as a modulator of coenzyme
A (CoA) levels in cell biology and disease models─especially for pantothenate kinase …
A (CoA) levels in cell biology and disease models─especially for pantothenate kinase …
Subcortical brain volume differences in participants with attention deficit hyperactivity disorder in children and adults: a cross-sectional mega-analysis
…, J Oosterlaan, G von Polier, K Konrad… - The Lancet …, 2017 - thelancet.com
Background Neuroimaging studies have shown structural alterations in several brain regions
in children and adults with attention deficit hyperactivity disorder (ADHD). Through the …
in children and adults with attention deficit hyperactivity disorder (ADHD). Through the …
[HTML][HTML] Subcortical brain volume differences of participants with ADHD across the lifespan: an ENIGMA collaboration
…, J Oosterlaan, G von Polier, K Konrad… - The Lancet …, 2017 - ncbi.nlm.nih.gov
BACKGROUND Neuroimaging studies show structural alterations in several brain regions
in children and adults with attention-deficit/hyperactivity disorder (ADHD). Through the …
in children and adults with attention-deficit/hyperactivity disorder (ADHD). Through the …
Overcoming synthetic challenges in targeting coenzyme A biosynthesis with the antimicrobial natural product CJ-15,801
…, R van der Westhuyzen, AR Hamann, KJ Mostert… - …, 2019 - pubs.rsc.org
The biosynthesis of the essential metabolic cofactor coenzyme A (CoA) has been receiving
increasing attention as a new target that shows potential to counter the rising resistance to …
increasing attention as a new target that shows potential to counter the rising resistance to …
Harnessing the Vnn1 pantetheinase pathway boosts short chain fatty acids production and mucosal protection in colitis
…, JJ Martinez-Garcia, F Tranchida, L Shintu, K Mostert… - Gut, 2023 - gut.bmj.com
… Konrad Mostert8, … infiltration in ulcerative areas in WT and VIVA colons exposed to DSS
and quantification in (J). (K) qRT-PCR analysis of the monocyte attractant chemokine MCP1/…
and quantification in (J). (K) qRT-PCR analysis of the monocyte attractant chemokine MCP1/…
[PDF][PDF] Developing Pantetheinase Developing Pantetheinase-Resistant Pantothenamide Antibacterials Resistant Pantothenamide Antibacterials Resistant …
L Barnard, KJ Mostert, WAL van Otterlo, E Strauss - researchgate.net
Pantothenamides (PanAms) are analogues of pantothenate, the biosynthetic precursor of
coenzyme A (CoA), and show potent antimicrobial activity against several bacteria and the …
coenzyme A (CoA), and show potent antimicrobial activity against several bacteria and the …
[HTML][HTML] Deviant white matter structure in adults with attention-deficit/hyperactivity disorder points to aberrant myelination and affects neuropsychological performance
…, M Hoogman, JC Mostert, J Dammers… - Progress in Neuro …, 2015 - Elsevier
Attention-deficit/hyperactivity disorder (ADHD) in childhood is characterized by gray and
white matter abnormalities in several brain areas. Considerably less is known about white …
white matter abnormalities in several brain areas. Considerably less is known about white …
[HTML][HTML] Characterising resting-state functional connectivity in a large sample of adults with ADHD
JC Mostert, E Shumskaya, M Mennes… - Progress in Neuro …, 2016 - Elsevier
Attention-deficit/hyperactivity disorder (ADHD) is a common childhood psychiatric disorder
that often persists into adulthood. While several studies have identified altered functional …
that often persists into adulthood. While several studies have identified altered functional …