Objectives: To prospectively evaluate the safety and efficacy of combined unenhanced and
gadoxetic acid disodium (Gd-EOB-DTPA)-enhanced magnetic resonance (MR) imaging …

Exosome-mediated signal transportation plays a variety of critical roles in cancer progression
and metastasis. From the aspect of cancer diagnosis, circulating exosomes are ideal …

Although the physiologic significance of lysine methylation of histones is well known, whether
lysine methylation plays a role in the regulation of nonhistone proteins has not yet been …

Metastasis is associated with poor prognosis in cancers. Exosomes, which are packed with
RNA and proteins and are released in all biological fluids, are emerging as an important …

We previously reported MELK (maternal embryonic leucine zipper kinase) as a novel
therapeutic target for breast cancer. MELK was also reported to be highly upregulated in multiple …

Histone proteins are modified in response to various external signals; however, their
mechanisms are still not fully understood. Citrullination is a post-transcriptional modification that …

Infection with CagA-producing Helicobacter pylori plays a causative role in the development
of gastric cancer. Upon delivery into gastric epithelial cells, CagA deregulates prooncogenic …

Uric acid (UA) is the end product of purine metabolism and can reportedly act as an antioxidant.
However, recently, numerous clinical and basic research approaches have revealed …

Upon a wide range of cellular stresses, p53 is activated and inhibits malignant transformation
through the transcriptional regulation of its target genes related to apoptosis, cell cycle …

CagA, encoded by cytotoxin-associated gene A (cagA), is a major virulence factor of
Helicobacter pylori, a gastric pathogen involved in the development of upper gastrointestinal …