The endoplasmic reticulum (ER) plays a critical role in the synthesis and chaperoning of
membrane-associated and secreted proteins. The membrane is also an important site of Ca 2+ …

Calreticulin is a ubiquitous Ca 2+ binding protein, located in the endoplasmic reticulum lumen,
which has been implicated in many diverse functions including: regulation of intracellular …

To test the role of ER luminal environment in apoptosis, we generated HeLa cell lines
inducible with respect to calreticulin and calnexin and investigated their sensitivity to drug-…

Calreticulin is a Ca 2+ -binding chaperone in the endoplasmic reticulum (ER), and calreticulin
gene knockout is embryonic lethal. Here, we used calreticulin-deficient mouse embryonic …

MHC class I molecules expressed in a calreticulin-deficient cell line (K42) assembled with β
2-microglobulin (β2-m) normally, but their subsequent loading with optimal peptides was …

Experimental injury is useful to induce tissue stem cells, which may exist in small numbers
under normal conditions. The salivary glands originate from the endoderm and consist of …

To study the role of calreticulin in Ca 2+ homeostasis and apoptosis, we generated cells
inducible for full-length or truncated calreticulin and measured Ca 2+ signals within the cytosol, …

Tissue damage can be assessed based on regenerative responses, including progenitor cell
proliferation. In the salivary gland, tissue damage induced by ligation of main ducts leads …

The urea cycle is a metabolic pathway for the disposal of excess nitrogen, which arises
primarily as ammonia. Nitrogen is essential for growth and life-maintenance, but excessive …

Perinatal exposure to excess iodine can lead to transient hypothyroidism in the newborn. In
Japan, large quantities of iodine-rich seaweed such as kombu (Laminaria japonica) are …