Hereditary defects in the repair of DNA damage are implicated in a variety of diseases, many
of which are typified by neurological dysfunction and/or increased genetic instability and …

DNA single-strand breaks can arise indirectly, as normal intermediates of DNA base excision
repair, or directly from damage to deoxyribose. Because single-strand breaks are induced …

Each day tens of thousands of DNA single-strand breaks (SSBs) arise in every cell from the
attack of deoxyribose and DNA bases by reactive oxygen species and other electrophilic …

The DNA repair proteins XRCC1 and DNA ligase III are physically associated in human cells
and directly interact in vitro and in vivo. Here, we demonstrate that XRCC1 is additionally …

The molecular role of poly (ADP‐ribose) polymerase‐1 in DNA repair is unclear. Here, we
show that the single‐strand break repair protein XRCC1 is rapidly assembled into discrete …

XRCC1 protein is required for DNA single-strand break repair and genetic stability but its
biochemical role is unknown. Here, we report that XRCC1 interacts with human polynucleotide …

XRCC1, the human gene that fully corrects the Chinese hamster ovary DNA repair mutant
EM9, encodes a protein involved in the rejoining of DNA single-strand breaks that arise …

Spinocerebellar ataxia with axonal neuropathy-1 (SCAN1) is a neurodegenerative disease
that results from mutation of tyrosyl phosphodiesterase 1 (TDP1) 1 . In lower eukaryotes, …

Topoisomerases regulate DNA topology and are fundamental to many aspects of chromosome
metabolism 1 , 2 . Their activity involves the transient cleavage of DNA, which, if it occurs …

Ataxia oculomotor apraxia-1 (AOA1) is a neurological disorder caused by mutations in the
gene (APTX) encoding aprataxin 1 , 2 . Aprataxin is a member of the histidine triad (HIT) family …