Value of in vivo α‐synuclein deposits in Parkinson's disease: A systematic review and meta‐analysis

K Tsukita, H Sakamaki‐Tsukita, K Tanaka… - Movement …, 2019 - Wiley Online Library
Previous studies that have investigated the potential of in vivo abnormal α‐synuclein
deposits as a pathological biomarker for PD included few participants and reported different …

Phase separation of an actin nucleator by junctional microtubules regulates epithelial function

K Tsukita, M Kitamata, H Kashihara, T Yano… - Science …, 2023 - science.org
Liquid-liquid phase separation (LLPS) is involved in various dynamic biological phenomena.
In epithelial cells, dynamic regulation of junctional actin filaments tethered to the apical …

Long-term effect of regular physical activity and exercise habits in patients with early Parkinson disease

K Tsukita, H Sakamaki-Tsukita, R Takahashi - Neurology, 2022 - AAN Enterprises
Background and Objectives Owing to the lack of long-term observations or comprehensive
adjustment for confounding factors, reliable conclusions regarding long-term effects of …

A microtubule‐LUZP1 association around tight junction promotes epithelial cell apical constriction

T Yano, K Tsukita, H Kanoh, S Nakayama… - The EMBO …, 2021 - embopress.org
Apical constriction is critical for epithelial morphogenesis, including neural tube formation.
Vertebrate apical constriction is induced by di‐phosphorylated myosin light chain (ppMLC)‐…

High-throughput CSF proteomics and machine learning to identify proteomic signatures for Parkinson disease development and progression

K Tsukita, H Sakamaki-Tsukita, S Kaiser, L Zhang… - Neurology, 2023 - AAN Enterprises
Background and Objectives This study aimed to identify CSF proteomic signatures characteristic
of Parkinson disease (PD) and evaluate their clinical utility. Methods This observational …

[HTML][HTML] Reciprocal association between the apical junctional complex and AMPK: a promising therapeutic target for epithelial/endothelial barrier function?

K Tsukita, T Yano, A Tamura, S Tsukita - International Journal of …, 2019 - mdpi.com
Epithelial/endothelial cells adhere to each other via cell–cell junctions including tight junctions
(TJs) and adherens junctions (AJs). TJs and AJs are spatiotemporally and functionally …

Dual-color live imaging unveils stepwise organization of multiple basal body arrays by cytoskeletons

…, T Katsuno, H Kashihara, H Tanaka, K Tsukita… - EMBO …, 2024 - embopress.org
For mucociliary clearance of pathogens, tracheal multiciliated epithelial cells (MCCs) organize
coordinated beating of cilia, which originate from basal bodies (BBs) with basal feet (BFs) …

Vinculin is critical for the robustness of the epithelial cell sheet paracellular barrier for ions

…, H Tanaka, T Mizuno, H Kanoh, K Tsukita… - Life science …, 2019 - life-science-alliance.org
The paracellular barrier function of tight junctions (TJs) in epithelial cell sheets is robustly
maintained against mechanical fluctuations, by molecular mechanisms that are poorly …

Novel pathogenic VPS13A gene mutations in Japanese patients with chorea-acanthocytosis

…, T Fujii, K Tsukita, H Sakamaki-Tsukita… - Neurology …, 2019 - AAN Enterprises
Objective To identify mutations in vacuolar protein sorting 13A (VPS13A) for Japanese patients
with suspected chorea-acanthocytosis (ChAc). Methods We performed a comprehensive …

[HTML][HTML] Lower Circulating Lymphocyte Count Predicts ApoE ε4‐Related Cognitive Decline in Parkinson's Disease

K Tsukita, H Sakamaki‐Tsukita… - Movement Disorders, 2021 - ncbi.nlm.nih.gov
4. Dexter DT, Carayon A, Javoy-agid F, et al. Alterations in the levels of iron, ferritin and
other trace metals in parkinson's disease and other neurodegenerative diseases affecting …