How different integrins that bind to the same type of extracellular matrix protein mediate
specific functions is unclear. We report the functional analysis of β 1 - and α v -class integrins …

Processing of the amyloid precursor protein (APP) by β‐ and γ‐secretases leads to the
generation of amyloid‐β (Aβ) peptides with varying lengths. Particularly Aβ42 contributes to …

Integrins are pivotal proteins in cell–cell adhesion, signaling and apoptosis. These properties
render them attractive targets for drugs, especially those involved in cancer treatment. …

Starting from the first crystal structure of the extracellular segment of the α v β 3 integrin receptor
with a cyclic RGD ligand bound to the active site, structural models for the interactions of …

Heparin-induced thrombocytopenia (HIT) is the most frequent drug-induced immune
reaction affecting blood cells. Its antigen is formed when the chemokine platelet factor 4 (PF4) …

The structures of membrane transporters are still mostly unsolved. Only recently, the first two
high‐resolution structures of transporters of the major facilitator superfamily (MFS) were …

Despite their crucial importance for cellular function, little is known about the folding
mechanisms of membrane proteins. Recently details of the folding energy landscape were …

Dopamine offers the possibility to build polymer films on any substrates via an oxidative
process. This redox process cannot only be used for self‐oxidation in air, but also in an …

Cellular membranes have long served as an inspiration for nanomaterial research. The
preparation of ultrathin polydopamine (PDA) films with integrated protein pores containing …

For many applications, antibodies need to be engineered toward maximum affinity. Strategies
are in demand to especially optimize this process toward slower dissociation rates, which …