User profiles for Karl Harlos
 | Karl HarlosOxford University Verified email at strubi.ox.ac.uk Cited by 16287 |
Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL
WC Hon, MI Wilson, K Harlos, TDW Claridge… - Nature, 2002 - nature.com
Hypoxia-inducible factor-1 (HIF-1) is a transcriptional complex that controls cellular and systemic
homeostatic responses to oxygen availability 1 . HIF-1α is the oxygen-regulated subunit …
homeostatic responses to oxygen availability 1 . HIF-1α is the oxygen-regulated subunit …
A functional and structural basis for TCR cross-reactivity in multiple sclerosis
…, H Jacobsen, S Ikemizu, C Andersson, K Harlos… - Nature …, 2002 - nature.com
The multiple sclerosis (MS)-associated HLA major histocompatibility complex (MHC) class II
alleles DRB1*1501, DRB5*0101 and DQB1*0602 are in strong linkage disequilibrium, …
alleles DRB1*1501, DRB5*0101 and DQB1*0602 are in strong linkage disequilibrium, …
Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes
PENICILLIN antibiotics are all produced from fermentation-derived penicillins because their
chemical synthesis is not commercially viable. The key step in penicillin biosynthesis, in …
chemical synthesis is not commercially viable. The key step in penicillin biosynthesis, in …
Structural basis of substrate discrimination and integrin binding by autotaxin
Autotaxin (ATX, also known as ectonucleotide pyrophosphatase/phosphodiesterase-2,
ENPP2) is a secreted lysophospholipase D that generates the lipid mediator lysophosphatidic …
ENPP2) is a secreted lysophospholipase D that generates the lipid mediator lysophosphatidic …
Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase
Clavaminate synthase (CAS), a remarkable Fe (II)/2-oxoglutarate oxygenase, catalyzes
three separate oxidative reactions in the biosynthesis of clavulanic acid, a clinically used …
three separate oxidative reactions in the biosynthesis of clavulanic acid, a clinically used …
Initiation of T cell signaling by CD45 segregation at'close contacts'
It has been proposed that the local segregation of kinases and the tyrosine phosphatase CD45
underpins T cell antigen receptor (TCR) triggering, but how such segregation occurs and …
underpins T cell antigen receptor (TCR) triggering, but how such segregation occurs and …
Structure of human CD1b with bound ligands at 2.3 Å, a maze for alkyl chains
The human genome encodes five nonpolymorphic major histocompatibility complex class I–like
glycoproteins, CD1a to CD1e, that present lipid antigens for specific recognition by T …
glycoproteins, CD1a to CD1e, that present lipid antigens for specific recognition by T …
[PDF][PDF] Structure and dimerization of a soluble form of B7-1
…, RJC Gilbert, JA Fennelly, AV Collins, K Harlos… - Immunity, 2000 - cell.com
B7-1 (CD80) and B7-2 (CD86) are glycoproteins expressed on antigen-presenting cells. The
binding of these molecules to the T cell homodimers CD28 and CTLA-4 (CD152) generates …
binding of these molecules to the T cell homodimers CD28 and CTLA-4 (CD152) generates …
[HTML][HTML] A procedure for setting up high-throughput nanolitre crystallization experiments. Crystallization workflow for initial screening, automated storage, imaging and …
Crystallization trials at the Division of Structural Biology in Oxford are now almost exclusively
carried out using a high-throughput workflow implemented in the Oxford Protein Production …
carried out using a high-throughput workflow implemented in the Oxford Protein Production …
An extracellular steric seeding mechanism for Eph-ephrin signaling platform assembly
E Seiradake, K Harlos, G Sutton, AR Aricescu… - Nature structural & …, 2010 - nature.com
Erythropoetin-producing hepatoma (Eph) receptors are cell-surface protein tyrosine kinases
mediating cell-cell communication. Upon activation, they form signaling clusters. We report …
mediating cell-cell communication. Upon activation, they form signaling clusters. We report …