Collagen is most abundant in animal tissues as very long fibrils with a characteristic axial
periodic structure. The fibrils provide the major biomechanical scaffold for cell attachment and …

Decorin is a member of the expanding group of widely distributed small leucine-rich proteoglycans
that are expected to play important functions in tissue assembly. We report that mice …

1956 some simple imperfections have been visualised in crystal structures of model
peptides (Bella et al., 2006). Integrin adhesion sequences [eg Arg-Gly-Asp (RGD) and Gly-Phe-O-…

Collagen fibrils in the extracellular matrix allow connective tissues such as tendon, skin and
bone to withstand tensile forces. The fibrils are indeterminate in length, insoluble and form …

Collagens are triple helical proteins that occur in the extracellular matrix (ECM) and at the
cell–ECM interface. There are more than 30 collagens and collagen-related proteins but the …

Type I procollagen was purified from the medium of cultured human fibroblasts incubated with
14C-labeled amino acids, the NH2-terminal propeptides were cleaved with procollagen N-…

The functional properties of tendon require an extracellular matrix (ECM) rich in elongated
collagen fibrils in parallel register. We sought to understand how embryonic fibroblasts …

The ability of the cornea to transmit light while being mechanically resilient is directly attributable
to the formation of an extracellular matrix containing orthogonal sheets of collagen fibrils…

Collagen fibrils are the major tensile element in vertebrate tissues, in which they occur as
ordered bundles in the extracellular matrix. Abnormal fibril assembly and organization results …

This article is one of a series, summarizing views expressed at the Orthopaedic Research
Society New Frontiers in Tendon Research Conference. This particular article reviews the …