The vascular adventitia acts as a biological processing center for the retrieval, integration,
storage, and release of key regulators of vessel wall function. It is the most complex …

Hypoxic pulmonary hypertension (PH) comprises a heterogeneous group of diseases
sharing the common feature of chronic hypoxia-induced pulmonary vascular remodeling. The …

Abstract Changes in the maternal environment leading to an altered intrauterine milieu can
result in subtle insults to the fetus, promoting increased lifetime disease risk and/or disease …

Macrophage-specific expression of Arginase-1 is commonly believed to promote inflammation,
fibrosis, and wound healing by enhancing L-proline, polyamine, and Th2 cytokine …

… /EBPβ is an essential component of Arg1 induction by the IL-4–STAT6 pathway 26 , we tested
whether C/EBPβ is also required for Arg1 expression … Karim C El Kasmi … Karim C El Kasmi …

Background— Ischemic preconditioning provides strong cardioprotection from ischemia, but
its molecular mechanisms remain unknown. Convincing evidence confirms a central role of …

Lymphocyte activation gene 3 (LAG-3) is a CD4-related, activation-induced cell surface
molecule expressed by various lymphoid cell types and binds to MHC class II with high affinity. …

Maternal obesity is associated with increased risk for offspring obesity and non-alcoholic
fatty liver disease (NAFLD), but the causal drivers of this association are unclear. Early …

Persistent accumulation of monocytes/macrophages in the pulmonary artery adventitial/perivascular
areas of animals and humans with pulmonary hypertension has been documented. …

Although many cytokine receptors generate their signals via the STAT3 pathway, the IL-10R
appears unique in promoting a potent anti-inflammatory response (AIR) via STAT3 to …