Abstract Treatment of cocaine addiction is hampered by high rates of relapse even after
prolonged drug abstinence. This relapse to compulsive cocaine use can be triggered by re-…

HLA-DR, Iba1 and CD68 are widely used microglia markers in human tissue. However, due
to differences in gene regulation, they may identify different activation stages of microglia. …

Here we report the transcriptional profile of human microglia, isolated from normal-appearing
grey matter (GM) and white matter (WM) of multiple sclerosis (MS) and non-neurological …

Autotaxin (ATX) is a secreted nucleotide pyrophosphatase/phosphodiesterase that functions
as a lysophospholipase D to produce the lipid mediator lysophosphatidic acid (LPA), a …

Much is still unknown about mechanisms underlying the phenotypical and functional versatility
of human microglia. Therefore, we developed a rapid procedure to isolate pure microglia …

Drugs that increase 26S proteasome activity have potential therapeutic applications in the
treatment of neurodegenerative diseases. A chemical genetics screen of over 2,750 …

Vitamin D deficiency has been implicated as a risk factor for multiple sclerosis (MS), but how
vitamin D metabolism affects MS pathophysiology is not understood. We studied the …

In multiple sclerosis (MS), activated microglia and infiltrating macrophages phagocytose myelin
focally in (chronic) active lesions. These demyelinating sites expand in time, but at some …

The Androgen Receptor (AR) is the key-driving transcription factor in prostate cancer, tightly
controlled by epigenetic regulation. To date, most epigenetic profiling has been performed …

Microglia are key players in the central nervous system in health and disease. Much
pioneering research on microglia function has been carried out in vivo with the use of genetic …