DNA damage is increased in Alzheimer’s disease (AD), while the underlying mechanisms
are unknown. Here, we employ comprehensive phosphoproteome analysis, and identify …

Brain inflammation generally accompanies and accelerates neurodegeneration. Here we
report a microglial mechanism in which polyglutamine binding protein 1 (PQBP1) senses …

Tau aggregation is a central hallmark of tauopathies such as frontotemporal lobar degeneration
and progressive supranuclear palsy as well as of Alzheimer’s disease, and it has been a …

We developed a new technique to observe macroautophagy in the brain in vivo and examined
whether fasting induced macroautophagy in neurons and how the induction was different …

The timing and characteristics of neuronal death in Alzheimer’s disease (AD) remain largely
unknown. Here we examine AD mouse models with an original marker, myristoylated …

Early-phase pathologies of Alzheimer’s disease (AD) are attracting much attention after
clinical trials of drugs designed to remove beta-amyloid (Aβ) aggregates failed to recover …

The molecular pathological mechanisms underlying schizophrenia remain unclear; however,
genomic analysis has identified genes encoding important risk molecules. One such …

The early-stage pathologies of frontotemporal lobal degeneration (FTLD) remain largely
unknown. In VCP T262A -KI mice carrying VCP gene mutation linked to FTLD, insufficient DNA …

From genetic and etiological studies, autoimmune mechanisms underlying schizophrenia
are suspected; however, the details remain unclear. In this study, we describe autoantibodies …

DNA damage and repair is a critical domain of many neurodegenerative diseases. In this
study, we focused on RpA1, a candidate key molecule in polyQ disease pathologies, and …