Germline mutations in telomere biology genes cause dyskeratosis congenita (DC), an
inherited bone marrow failure and cancer predisposition syndrome. DC is a clinically …

This study proposes a fuzzy time series forecasting method based on hesitant fuzzy sets for
forecasting in the environment of hesitant information. The proposed method addresses the …

Multiple myeloma (MM) is the second most common hematological cancer and is characterized
by genetic features including translocations, chromosomal copy number aberrations, …

Chromosomal aberrations are a hallmark of human cancers, with complex cytogenetic
rearrangements leading to genetic changes permissive for cancer initiation and progression. …

Mammalian chromosomes terminate in stretches of repetitive telomeric DNA that act as
buffers to avoid loss of essential genetic information during end-replication. A multiprotein …

While the past decade has seen meaningful improvements in clinical outcomes for multiple
myeloma patients, a subset of patients does not benefit from current therapeutics for unclear …

Tankyrase 1 is a poly (ADP-ribose) polymerase (PARP) that participates in a broad range of
cellular activities due to interaction with multiple binding partners. Tankyrase 1 recognizes a …

Sister chromatid cohesion relies on cohesin, a complex comprising a tri-partite ring and a
peripheral subunit Scc3, which is found as two related isoforms SA1 and SA2 in vertebrates. …

Rickettsial diseases (RD) are widely reported all over the world. Scrub typhus (ST) is a major
tropical infection which is well documented all over India. Therefore, the index of suspicion …

Telomerase replicates chromosome ends to facilitate continued cell division. Mutations that
compromise telomerase function result in stem cell failure diseases, such as dyskeratosis …