Neocortical inhibitory neurons exhibit remarkably diverse morphology, physiological properties
and connectivity. Genetic access to molecularly defined subtypes of inhibitory neurons …

Although senile plaques focally disrupt neuronal health, the functional response of astrocytes
to Alzheimer's disease pathology is unknown. Using multiphoton fluorescence lifetime …

Alzheimer's disease is characterized by the deposition of senile plaques and progressive
dementia. The molecular mechanisms that couple plaque deposition to neural system failure, …

Physical features of sensory stimuli are fixed, but sensory perception is context dependent.
The precise mechanisms that govern contextual modulation remain unknown. Here, we …

Neuronal intracellular chloride concentration [Cl – ] i is an important determinant of γ-aminobutyric
acid type A (GABA A ) receptor (GABA A R)–mediated inhibition and cytoplasmic …

Alzheimer's disease (AD) is pathologically characterized by the deposition of extracellular
amyloid-β plaques and intracellular aggregation of tau protein in neurofibrillary tangles (NFTs) …

Seizures induce excitatory shifts in the reversal potential for GABA A -receptor-mediated
responses, which may contribute to the intractability of electro-encephalographic seizures and …

Previous clinical studies have documented a close relationship between cerebrovascular
disease and risk of Alzheimer's disease. We examined possible mechanistic interactions …

Electroclinical uncoupling of neonatal seizures refers to electrographic seizure activity that
is not clinically manifest. Uncoupling increases after treatment with Phenobarbital, which …

Cholinergic basal forebrain (CBF) signaling exhibits multiple timescales of activity with
classic slow signals related to brain and behavioral states and fast, phasic signals reflecting …