Primary ciliary dyskinesia most often arises from loss of the dynein motors that power ciliary
beating. Here we show that DNAAF3 (also known as PF22), a previously uncharacterized …

Cilia and flagella are evolutionarily conserved structures that play various physiological roles
in diverse cell types. Defects in motile cilia result in primary ciliary dyskinesia (PCD), the …

Gender differences have been described in the response of the cardiovascular system to a
number of stimuli, including ventricular remodeling in response to pressure overload, but the …

We previously found that a mutation at the ODA7 locus in Chlamydomonas prevents axonemal
outer row dynein assembly by blocking association of heavy chains and intermediate …

The Chlamydomonas reinhardtii oda8 mutation blocks assembly of flagellar outer dynein
arms (ODAs), and interacts genetically with ODA5 and ODA10, which encode axonemal …

The last stage of cell division involves two daughter cells remaining interconnected by a
cytokinetic bridge that is cleaved during abscission. Conserved between the zebrafish embryo …

An essential process during Danio rerio’s left-right organizer (Kupffer’s Vesicle, KV) formation
is the formation of a motile cilium by developing KV cells which extends into the KV lumen. …

We propose to understand how the mitotic kinase PLK1 drives chromosome segregation
errors, with a specific focus on Gravin, a PLK1 scaffold. In both three-dimensional primary …

Polo-like-kinase (PLK) 1 activity is associated with maintaining the functional and physical
properties of the centrosome’s pericentriolar matrix (PCM). In this study, we use a multimodal …

The mitotic kinase, polo-like kinase 1 (PLK1), facilitates the assembly of the two mitotic spindle
poles, which are required for the formation of the microtubule-based spindle that ensures …