Human endogenous retrovirus K triggers an antigen-specific immune response in breast cancer patients
F Wang-Johanning, L Radvanyi, K Rycaj, JB Plummer… - Cancer research, 2008 - AACR
Recent evidence indicates that human cancer cells reactivate the expression of latent
human endogenous retroviral (HERV) proteins. However, the extent to which cancer patients …
human endogenous retroviral (HERV) proteins. However, the extent to which cancer patients …
Genetic engineering of T cells to target HERV-K, an ancient retrovirus on melanoma
…, KC Switzer, S Olivares, SN Maiti, JB Plummer… - Clinical Cancer …, 2015 - AACR
Purpose: The human endogenous retrovirus (HERV-K) envelope (env) protein is a tumor-associated
antigen (TAA) expressed on melanoma but not normal cells. This study was …
antigen (TAA) expressed on melanoma but not normal cells. This study was …
Immunotherapeutic potential of anti-human endogenous retrovirus-K envelope protein antibodies in targeting breast tumors
…, K Rycaj, JB Plummer, M Li, B Yin… - Journal of the …, 2012 - academic.oup.com
Background The envelope (env) protein of the human endogenous retrovirus type K (HERV-K)
family is commonly expressed on the surface of breast cancer cells. We assessed …
family is commonly expressed on the surface of breast cancer cells. We assessed …
Human endogenous retrovirus type K antibodies and mRNA as serum biomarkers of early‐stage breast cancer
A simple and accurate test to detect early‐stage breast cancer has not been developed.
Previous studies indicate that the level of human endogenous retrovirus type K (group HERV‐K(…
Previous studies indicate that the level of human endogenous retrovirus type K (group HERV‐K(…
Cytotoxicity of human endogenous retrovirus K–specific T cells toward autologous ovarian cancer cells
K Rycaj, JB Plummer, B Yin, M Li, J Garza… - Clinical Cancer …, 2015 - AACR
Purpose: To determine whether HERV-K envelope (ENV) protein could function as a tumor-associated
antigen and elicit specific T-cell responses against autologous ovarian cancer …
antigen and elicit specific T-cell responses against autologous ovarian cancer …
Expression of human endogenous retrovirus type K envelope protein is a novel candidate prognostic marker for human breast cancer
…, K Rycaj, S Geng, M Li, JB Plummer, B Yin… - Genes & …, 2011 - journals.sagepub.com
We previously observed that the HERV type K (HERV-K) envelope (env) protein was expressed
in the majority of human breast tumors from a US cohort of women from Texas. We also …
in the majority of human breast tumors from a US cohort of women from Texas. We also …
Transcriptional activation of MYC-induced genes by GCN5 promotes B-cell lymphomagenesis
Our results provide important proof of principle for Gcn5 functions in formation and progression
of Myc-driven cancers, suggesting that GCN5 may be a viable target for development of …
of Myc-driven cancers, suggesting that GCN5 may be a viable target for development of …
Enhanced CD19 activity in B cells contributes to immunodeficiency in mice deficient in the ICF syndrome gene Zbtb24
…, S Hardikar, JB Plummer, T Hamidi, B Liu… - Cellular & Molecular …, 2023 - nature.com
Immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome is a rare
autosomal recessive disorder characterized by DNA hypomethylation and antibody deficiency. …
autosomal recessive disorder characterized by DNA hypomethylation and antibody deficiency. …
Divergent structures of mammalian and gammaherpesvirus uracil DNA glycosylases confer distinct DNA binding and substrate activity
Uracil DNA glycosylase (UNG) removes mutagenic uracil base from DNA to initiate base
excision repair (BER). The result is an abasic site (AP site) that is further processed by the high-…
excision repair (BER). The result is an abasic site (AP site) that is further processed by the high-…
Gammaherpesvirus-infected germinal center cells express a distinct immunoglobulin repertoire
…, Q Dong, JB Plummer, Y Zhong, B Liu… - Life science …, 2020 - life-science-alliance.org
The gammaherpesviruses (γHVs), human Kaposi sarcoma-associated herpesvirus (KSHV),
EBV, and murine γHV68 are prevalent infections associated with lymphocyte pathologies. …
EBV, and murine γHV68 are prevalent infections associated with lymphocyte pathologies. …