User profiles for John R Weir

John R. Weir

- Verified email at tuebingen.mpg.de - Cited by 3758

John R Weir

- Verified email at okstate.edu - Cited by 1361

Structure of the 70S Ribosome Complexed with mRNA and tRNA

…, A Weixlbaumer, S Petry, AC Kelley, JR Weir… - Science, 2006 - science.org
The crystal structure of the bacterial 70S ribosome refined to 2.8 angstrom resolution reveals
atomic details of its interactions with messenger RNA (mRNA) and transfer RNA (tRNA). A …

The crystal structure of the ribosome bound to EF-Tu and aminoacyl-tRNA

…, AC Kelley, YG Gao, FV Murphy IV, JR Weir… - Science, 2009 - science.org
The ribosome selects a correct transfer RNA (tRNA) for each amino acid added to the
polypeptide chain, as directed by messenger RNA. Aminoacyl-tRNA is delivered to the ribosome …

Bub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signaling

I Primorac, JR Weir, E Chiroli, F Gross, I Hoffmann… - Elife, 2013 - elifesciences.org
10.7554/eLife.01030.001 Regulation of macromolecular interactions by phosphorylation is
crucial in signaling networks. In the spindle assembly checkpoint (SAC), which enables …

The rising Great Plains fire campaign: citizens' response to woody plant encroachment

…, CL Wonkka, DM Engle, JR Weir… - Frontiers in Ecology …, 2013 - Wiley Online Library
Despite years of accumulating scientific evidence that fire is critical for maintaining the structure
and function of grassland ecosystems in the US Great Plains, fire has not been restored …

CENP-C is a blueprint for constitutive centromere–associated network assembly within human kinetochores

K Klare, JR Weir, F Basilico, T Zimniak… - Journal of Cell …, 2015 - rupress.org
Kinetochores are multisubunit complexes that assemble on centromeres to bind spindle
microtubules and promote faithful chromosome segregation during cell division. A 16-subunit …

GTPase activation of elongation factor EF‐Tu by the ribosome during decoding

JC Schuette, FV Murphy IV, AC Kelley, JR Weir… - The EMBO …, 2009 - embopress.org
We have used single‐particle reconstruction in cryo‐electron microscopy to determine a
structure of the Thermus thermophilus ribosome in which the ternary complex of elongation …

Insights from biochemical reconstitution into the architecture of human kinetochores

JR Weir, AC Faesen, K Klare, A Petrovic, F Basilico… - Nature, 2016 - nature.com
Chromosomes are carriers of genetic material and their accurate transfer from a mother cell
to its two daughters during cell division is of paramount importance for life. Kinetochores are …

Structural analysis reveals the characteristic features of Mtr4, a DExH helicase involved in nuclear RNA processing and surveillance

JR Weir, F Bonneau, J Hentschel… - Proceedings of the …, 2010 - National Acad Sciences
Mtr4 is a conserved RNA helicase that functions together with the nuclear exosome. It participates
in the processing of structured RNAs, including the maturation of 5.8S ribosomal RNA (…

The pseudo GTPase CENP-M drives human kinetochore assembly

F Basilico, S Maffini, JR Weir, D Prumbaum, AM Rojas… - Elife, 2014 - elifesciences.org
10.7554/eLife.02978.001 Kinetochores, multi-subunit complexes that assemble at the interface
with centromeres, bind spindle microtubules to ensure faithful delivery of chromosomes …

[HTML][HTML] Progress in the structural and functional characterization of kinetochores

ME Pesenti, JR Weir, A Musacchio - Current opinion in structural biology, 2016 - Elsevier
… Author links open overlay panel Marion E Pesenti 1 , John R Weir 1 , Andrea Musacchio 1 2
… the CENP-O:CENP-P:CENP-Q:CENP-R:CENP-U sub-complex (CENP-OPQRU, which can …