Cells’ local mechanical environment can be as important in guiding cellular responses as
many well-characterized biochemical cues. Hydrogels that mimic the native extracellular …

Tendon is an intricately organized connective tissue that efficiently transfers muscle force to
the bony skeleton. Its structure, function, and physiology reflect the extreme, repetitive …

Concurrent with a progressive loss of regenerative capacity, connective tissue aging is
characterized by a progressive accumulation of Advanced Glycation End-products (AGEs). …

The non-enzymatic reaction of proteins with glucose (glycation) is a topic of rapidly growing
importance in human health and medicine. There is increasing evidence that this reaction …

Current scientific attempts to generate in vitro tissue-engineered living blood vessels (TEBVs)
show substantial limitations, thereby preventing routine clinical use. In the present report, …

Shoulders with supraspinatus (SSP) tears are associated with significantly larger critical
shoulder angles (CSA) compared to disease‐free shoulders. We hypothesized that larger CSAs …

Connective tissue aging and diabetes related comorbidity are associated with compromised
tissue function, increased susceptibility to injury, and reduced healing capacity. This has …

The glycosaminoglycan (GAG) dermatan sulfate and chondroitin sulfate side-chains of small
leucine-rich proteoglycans have been increasingly posited to act as molecular cross links …

This study was performed to characterize the mechanical properties of the kidney capsular
membrane at strain-rates associated with blunt abdominal trauma. Uniaxial quasi-static and …

Substrates with mechanical property gradients and various extracellular matrix ligand
loadings were evaluated for their ability to direct bone marrow stromal cell differentiation along …