m6A in mRNA: an ancient mechanism for fine-tuning gene expression

JY Roignant, M Soller - Trends in Genetics, 2017 - cell.com
Modifications in mRNA constitute ancient mechanisms to regulate gene expression post-transcriptionally.
N 6 -methyladenosine (m 6 A) is the most prominent mRNA modification, and …

m6A modulates neuronal functions and sex determination in Drosophila

…, MA Andrade-Navarro, B Poeck, M Helm, JY Roignant - Nature, 2016 - nature.com
N 6 -methyladenosine RNA (m 6 A) is a prevalent messenger RNA modification in vertebrates.
Although its functions in the regulation of post-transcriptional gene expression are …

[HTML][HTML] Quantifying post-transcriptional regulation in the development of Drosophila melanogaster

…, M Dejung, S Sayols, C Kreutz, JY Roignant… - Nature …, 2018 - nature.com
Even though proteins are produced from mRNA, the correlation between mRNA levels and
protein abundances is moderate in most studies, occasionally attributed to complex post-…

[HTML][HTML] Pattern formation in the Drosophila eye disc

JY Roignant, JE Treisman - The International journal of …, 2009 - ncbi.nlm.nih.gov
Differentiation of the Drosophila compound eye from the eye imaginal disc is a progressive
process: columns of cells successively differentiate in a posterior to anterior sequence, …

[HTML][HTML] Anything but ordinary–emerging splicing mechanisms in eukaryotic gene regulation

NH Gehring, JY Roignant - Trends in Genetics, 2021 - cell.com
Splicing of precursor mRNAs (pre-mRNA) is an important step during eukaryotic gene
expression. The identification of the actual splice sites and the proper removal of introns are …

Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl (2) d

…, M Helm, M Soller, M Bühler, JY Roignant - Genes & …, 2018 - genesdev.cshlp.org
N 6-methyladenosine (m 6 A) is the most abundant mRNA modification in eukaryotes,
playing crucial roles in multiple biological processes. m 6 A is catalyzed by the activity of …

Absence of transitive and systemic pathways allows cell-specific and isoform-specific RNAi in Drosophila

JY Roignant, C Carré, B Mugat, D Szymczak… - Rna, 2003 - rnajournal.cshlp.org
RNA interference (RNAi) designates the multistep process by which double-stranded RNA
induces the silencing of homologous endogenous genes. Some aspects of RNAi appear to …

[HTML][HTML] Hakai is required for stabilization of core components of the m6A mRNA methylation machinery

…, P Beli, M Helm, M Jinek, M Soller, JY Roignant - Nature …, 2021 - nature.com
N 6 -methyladenosine (m 6 A) is the most abundant internal modification on mRNA which
influences most steps of mRNA metabolism and is involved in several biological functions. The …

The developmental proteome of Drosophila melanogaster

…, D Kappei, B Altenhein, JY Roignant… - Genome …, 2017 - genome.cshlp.org
Drosophila melanogaster is a widely used genetic model organism in developmental
biology. While this model organism has been intensively studied at the RNA level, a …

Ythdf is a N6‐methyladenosine reader that modulates Fmr1 target mRNA selection and restricts axonal growth in Drosophila

…, A Quattrone, A Soldano, JY Roignant - The EMBO …, 2021 - embopress.org
N6‐methyladenosine (m 6 A) regulates a variety of physiological processes through modulation
of RNA metabolism. This modification is particularly enriched in the nervous system of …