Protein function is often modulated by protein-protein interactions (PPIs) and therefore
defining the partners of a protein helps to understand its activity. PPIs can be detected through …

Nicotine dependence is linked to single nucleotide polymorphisms in the CHRNB4-CHRNA3-CHRNA5
gene cluster encoding the α3β4α5 nicotinic acetylcholine receptor (nAChR). …

Background Determining usefulness of biomedical text mining systems requires realistic task
definition and data selection criteria without artificial constraints, measuring performance …

The biomedical literature is represented by millions of abstracts available in the Medline
database. These abstracts can be queried with the PubMed interface, which provides a keyword…

The ELR + -CXCL chemokines have been described typically as potent chemoattractants
and activators of neutrophils during the acute phase of inflammation. Their role in …

Interactome maps are valuable resources to elucidate protein function and disease mechanisms.
Here, we report on an interactome map that focuses on neurodegenerative disease (…

Biomedical literature is traditionally used as a way to inform scientists of the relevance of
genes in relation to a research topic. However many genes, especially from poorly studied …

Understanding how distinct cell types arise from multipotent progenitor cells is a major quest
in stem cell biology. The liver and pancreas share many aspects of their early development …

Interactions of proteins regulate signaling, catalysis, gene expression and many other cellular
functions. Therefore, characterizing the entire human interactome is a key effort in current …

Background The constant evolving and development of next-generation sequencing
techniques lead to high throughput data composed of datasets that include a large number of …