Plasmodium falciparum resistance to artemisinin derivatives in southeast Asia threatens
malaria control and elimination activities worldwide. To monitor the spread of artemisinin …

Background Recent gains in reducing the global burden of malaria are threatened by the
emergence of Plasmodium falciparum resistance to artemisinins. The discovery that mutations …

Using reverse transcriptase–PCR and degenerate oligonucleotides derived from the active-site
residues of subtilisin/kexin-like serine proteinases, we have identified a highly …

Background Western Cambodia is the epicentre of Plasmodium falciparum multidrug resistance
and is facing high rates of dihydroartemisinin–piperaquine treatment failures. Genetic …

The declining efficacy of artemisinin derivatives against Plasmodium falciparum in western
Cambodia is a major concern. The knowledge gap in the understanding of the mechanisms …

Antibodies from hyperimmune monkey sera, selected by absorption to Plasmodium
falciparum-infected erythrocytes, and elution at acidic pH, allowed us to characterize a novel parasite …

Plasmodium and Toxoplasma are parasites of major medical importance that belong to the
Apicomplexa phylum of protozoa. These parasites transform into various stages during their …

Multigene families optimise fitness by providing a set of related genes with possibly different
temporal and/or topological expression patterns. We analyse here the structural …

We describe here a highly efficient procedure for conditional mutagenesis in Plasmodium.
The procedure uses the site-specific recombination FLP-FRT system of yeast and targets the …

The process of human erythrocyte invasion by Plasmodium falciparum parasites involves a
calcium-dependent serine protease with properties consistent with a subtilisin-like activity. …