User profiles for Jason Mercer
Jason MercerIMI University of Birmingham Verified email at bham.ac.uk Cited by 7848 |
Virus entry by endocytosis
J Mercer, M Schelhaas… - Annual review of …, 2010 - annualreviews.org
Although viruses are simple in structure and composition, their interactions with host cells
are complex. Merely to gain entry, animal viruses make use of a repertoire of cellular …
are complex. Merely to gain entry, animal viruses make use of a repertoire of cellular …
[HTML][HTML] Viral apoptotic mimicry
As opportunistic pathogens, viruses have evolved many elegant strategies to manipulate
host cells for infectious entry and replication. Viral apoptotic mimicry, defined by the exposure …
host cells for infectious entry and replication. Viral apoptotic mimicry, defined by the exposure …
Direct identification of ligand-receptor interactions on living cells and tissues
…, LM Henning, C Jost, A Plückthun, J Mercer… - Nature …, 2012 - nature.com
Many cellular responses are triggered by proteins, drugs or pathogens binding to cell-surface
receptors, but it can be challenging to identify which receptors are bound by a given ligand…
receptors, but it can be challenging to identify which receptors are bound by a given ligand…
Vaccinia extracellular virions enter cells by macropinocytosis and acid‐activated membrane rupture
Vaccinia virus (VACV), the model poxvirus, produces two types of infectious particles: mature
virions (MVs) and extracellular virions (EVs). EV particles possess two membranes and …
virions (MVs) and extracellular virions (EVs). EV particles possess two membranes and …
Nanoscale polarization of the entry fusion complex of vaccinia virus drives efficient fusion
To achieve efficient binding and subsequent fusion, most enveloped viruses encode between
one and five proteins 1 . For many viruses, the clustering of fusion proteins—and their …
one and five proteins 1 . For many viruses, the clustering of fusion proteins—and their …
Vaccinia virus uses macropinocytosis and apoptotic mimicry to enter host cells
J Mercer, A Helenius - Science, 2008 - science.org
Viruses employ many different strategies to enter host cells. Vaccinia virus, a prototype poxvirus,
enters cells in a pH-dependent fashion. Live cell imaging showed that fluorescent virus …
enters cells in a pH-dependent fashion. Live cell imaging showed that fluorescent virus …
Virus entry by macropinocytosis
J Mercer, A Helenius - Nature cell biology, 2009 - nature.com
As obligatory intracellular parasites, viruses rely on host-cell functions for most aspects of
their replication cycle. This is born out during entry, when most viruses that infect vertebrate …
their replication cycle. This is born out during entry, when most viruses that infect vertebrate …
[HTML][HTML] Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1
JC Mercer, WI DeHaven, JT Smyth, B Wedel… - Journal of Biological …, 2006 - ASBMB
The molecular nature of store-operated Ca 2+ -selective channels has remained an enigma,
due largely to the continued inability to convincingly demonstrate Ca 2+ -selective store-…
due largely to the continued inability to convincingly demonstrate Ca 2+ -selective store-…
Activation and regulation of store‐operated calcium entry
…, T Tomita, WI DeHaven, JC Mercer… - Journal of cellular …, 2010 - Wiley Online Library
… Jason C. Mercer… Mercer …
[HTML][HTML] Quantitative mapping and minimization of super-resolution optical imaging artifacts
Super-resolution microscopy depends on steps that can contribute to the formation of image
artifacts, leading to misinterpretation of biological information. We present NanoJ-…
artifacts, leading to misinterpretation of biological information. We present NanoJ-…