Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells

J Dörrie, H Gerauer, Y Wachter, SJ Zunino - Cancer research, 2001 - AACR
Resveratrol, a plant antibiotic, has been found to have anticancer activity and was recently
reported to induce apoptosis in the myeloid leukemia line HL60 by the CD95-CD95 ligand …

Targeting of DEC-205 on human dendritic cells results in efficient MHC class II–restricted antigen presentation

…, G Schuler, N Schaft, J Dörrie - Blood, The Journal …, 2010 - ashpublications.org
The use of dendritic cells (DCs) in therapeutic cancer vaccination requires their loading with
tumor-specific antigen(s). DEC-205, a phagocytosis receptor mediating antigen uptake, is …

[HTML][HTML] Redirecting T cells to Ewing's sarcoma family of tumors by a chimeric NKG2D receptor expressed by lentiviral transduction or mRNA transfection

M Lehner, G Götz, J Proff, N Schaft, J Dörrie, F Full… - PloS one, 2012 - journals.plos.org
We explored the possibility to target Ewing's sarcoma family of tumors (ESFT) by redirecting
T cells. To this aim, we considered NKG2D-ligands (NKG2D-Ls) as possible target antigens. …

Generation of an optimized polyvalent monocyte-derived dendritic cell vaccine by transfecting defined RNAs after rather than before maturation

N Schaft, J Dörrie, P Thumann, VE Beck… - The Journal of …, 2005 - journals.aai.org
Transfection with RNA is an attractive method of Ag delivery to dendritic cells (DCs), but has
not yet been standardized. We describe in this study the methods to efficiently generate an …

A new way to generate cytolytic tumor-specific T cells: electroporation of RNA coding for a T cell receptor into T lymphocytes

N Schaft, J Dörrie, I Müller, V Beck, S Baumann… - Cancer immunology …, 2006 - Springer
Effective T cell receptor (TCR) transfer until now required stable retroviral transduction.
However, retroviral transduction poses the threat of irreversible genetic manipulation of …

[HTML][HTML] RNA-transfection of γ/δ T cells with a chimeric antigen receptor or an α/β T-cell receptor: a safer alternative to genetically engineered α/β T cells for the …

…, U Uslu, G Schuler, KF Gerer, S Hoyer, J Dörrie… - BMC cancer, 2017 - Springer
Background Adoptive T-cell therapy relying on conventional T cells transduced with T-cell
receptors (TCRs) or chimeric antigen receptors (CARs) has caused substantial tumor …

Carnosol-induced apoptosis and downregulation of Bcl-2 in B-lineage leukemia cells

J Dörrie, K Sapala, SJ Zunino - Cancer letters, 2001 - Elsevier
Carnosol, a phenolic compound extracted from the herb rosemary has been reported to have
anti-cancer activity. We investigated whether carnosol was cytotoxic against several pro-B …

Norm-and hypo-fractionated radiotherapy is capable of activating human dendritic cells

…, A Allgäuer, B Frey, R Fietkau, J Dörrie… - Journal of …, 2014 - Taylor & Francis
Despite the transient immunosuppressive properties of local radiotherapy (RT), this classical
treatment modality of solid tumors is capable of inducing immunostimulatory forms of tumor-…

Mild hyperthermia enhances human monocyte-derived dendritic cell functions and offers potential for applications in vaccination strategies

I Knippertz, MF Stein, J Dörrie, N Schaft… - International Journal …, 2011 - Taylor & Francis
Dendritic cell (DC)-based immunotherapy has been shown to be a promising strategy for
anti-cancer therapy. Nevertheless, only a low overall clinical response rate has been observed …

The si RNA‐mediated downregulation of PD‐1 alone or simultaneously with CTLA‐4 shows enhanced in vitro CAR‐T‐cell functionality for further clinical development …

…, N Schaft, G Schuler, J Dörrie… - Experimental …, 2018 - Wiley Online Library
Chimeric antigen receptor ( CAR )‐T cells have been used successfully for cancer immunotherapy.
While substantial tumor regression was observed in leukaemia and lymphoma, CAR …