Studies in embryonic development have guided successful efforts to direct the differentiation
of human embryonic and induced pluripotent stem cells (PSCs) into specific organ cell …

Protein–protein interactions have a key role in most biological processes, and offer attractive
opportunities for therapeutic intervention. Developing small molecules that modulate protein…

A strategy, called alanine-scanning mutagenesis, was used to identify specific side chains
in human growth hormone (hGH) that strongly modulate binding to the hGH receptor cloned …

The x-ray crystal structure of the complex between human growth hormone (hGH) and the
extracellular domain of its first bound receptor (hGHbp) shows that about 30 side chains from …

Targeting the interfaces between proteins has huge therapeutic potential, but discovering
small-molecule drugs that disrupt protein–protein interactions is an enormous challenge. …

Somatic mutations in the small GTPase K-Ras are the most common activating lesions found
in human cancer, and are generally associated with poor response to standard therapies 1 …

Revised Manuscript Received May 29, 1990 e energetics of virtually all binding functions in
proteins is the culmination of a set of molecular interactions. For example, removal of a …

Recently it has been pointed out that the characteristic quantum-gravity scale could be as low
as the weak scale in theories with gravity propagating in higher dimensions. The observed …

The object of this book is a presentation of the major results relating to two geometrically
inspired problems in analysis. One is that of determining which metric spaces can be …

Taking seriously the phenomenological indications for supersymmetry we have made a
detailed study of unified minimal SUSY, including many effects at the few percent level in a …