Senescent human fibroblasts show increased glycolysis and redox homeostasis with extracellular metabolomes that overlap with those of irreparable DNA damage …
…, ED Karoly, SS Prime, EK Parkinson - Journal of proteome …, 2015 - ACS Publications
Cellular senescence can modulate various pathologies and is associated with irreparable
DNA double-strand breaks (IrrDSBs). Extracellular senescence metabolomes (ESMs) were …
DNA double-strand breaks (IrrDSBs). Extracellular senescence metabolomes (ESMs) were …
[PDF][PDF] T helper 2 cells control monocyte to tissue-resident macrophage differentiation during nematode infection of the pleural cavity
The recent revolution in tissue-resident macrophage biology has resulted largely from
murine studies performed in C57BL/6 mice. Here, using both C57BL/6 and BALB/c mice, we …
murine studies performed in C57BL/6 mice. Here, using both C57BL/6 and BALB/c mice, we …
[HTML][HTML] IL-17A both initiates, via IFNγ suppression, and limits the pulmonary type-2 immune response to nematode infection
Nippostrongylus brasiliensis is a well-defined model of type-2 immunity but the early lung-migrating
phase is dominated by innate IL-17A production. In this study, we confirm previous …
phase is dominated by innate IL-17A production. In this study, we confirm previous …
[HTML][HTML] Metabolic alterations in cellular senescence: the role of citrate in ageing and age-related disease
ME Mycielska, EN James, EK Parkinson - International Journal of …, 2022 - mdpi.com
… Parkinson, the Dunhill Medical Trust (grant number R452/1115) for the financial support of
Emma … The authors wish to thank Lindsay Parkinson for assistance with artwork and graphics. …
Emma … The authors wish to thank Lindsay Parkinson for assistance with artwork and graphics. …
Fibroblast activation and senescence in oral cancer
…, GJ Thomas, ENL James, EK Parkinson - Journal of oral …, 2017 - Wiley Online Library
… Recently, Parkinson and colleagues developed a new paradigm of OSCC and identified
genetically stable (GS-OSCC) and genetically unstable (GU-OSCC) epithelial subtypes in cell …
genetically stable (GS-OSCC) and genetically unstable (GU-OSCC) epithelial subtypes in cell …
Serum metabolomics in animal models and human disease
EL James, EK Parkinson - Current Opinion in Clinical Nutrition & …, 2015 - journals.lww.com
… ASSESSMENT OF NUTRITIONAL STATUS AND ANALYTICAL METHODS: Edited by
Kristina Norman and Dwight E. Matthews … James, Centre for Clinical and Diagnostic Oral …
Kristina Norman and Dwight E. Matthews … James, Centre for Clinical and Diagnostic Oral …
[HTML][HTML] Replicatively senescent human fibroblasts reveal a distinct intracellular metabolic profile with alterations in NAD+ and nicotinamide metabolism
…, JAE Lane, RD Michalek, ED Karoly, EK Parkinson - Scientific reports, 2016 - nature.com
Cellular senescence occurs by proliferative exhaustion (PEsen) or following multiple cellular
stresses but had not previously been subject to detailed metabolomic analysis. Therefore, …
stresses but had not previously been subject to detailed metabolomic analysis. Therefore, …
IL-13 deficiency exacerbates lung damage and impairs epithelial-derived type 2 molecules during nematode infection
AL Chenery, S Rosini, JE Parkinson… - Life Science …, 2021 - life-science-alliance.org
IL-13 is implicated in effective repair after acute lung injury and the pathogenesis of chronic
diseases such as allergic asthma. Both these processes involve matrix remodelling, but …
diseases such as allergic asthma. Both these processes involve matrix remodelling, but …
[HTML][HTML] Inflammasome-independent role for NLRP3 in controlling innate antihelminth immunity and tissue repair in the lung
…, Z Agha, J Ajendra, JE Parkinson… - The Journal of …, 2019 - journals.aai.org
… (E) Representative day 2 postinfection lung sections and lacunarity (scale bar, 500 μm). …
(E) Representative day 2 postinfection lung sections and lacunarity (scale bar, 500 μm). Data …
(E) Representative day 2 postinfection lung sections and lacunarity (scale bar, 500 μm). Data …
Areca nut alkaloids induce irreparable DNA damage and senescence in fibroblasts and may create a favourable environment for tumour progression
…, GN Pitiyage, ELN James, EK Parkinson - Journal of Oral …, 2016 - Wiley Online Library
… Pitiyage and EK Parkinson – unpublished data), and OSMF epithelium in situ shows more
oxidative DNA damage than the mesenchyme 11. Thus, it is possible that the direct induction …
oxidative DNA damage than the mesenchyme 11. Thus, it is possible that the direct induction …