Neurodegenerative diseases are a growing burden, and there is an urgent need for better
biomarkers for diagnosis, prognosis, and treatment efficacy. Structural and functional brain …

Gene and protein expression data provide useful resources for understanding brain function,
but little is known about the lipid composition of the brain. Here, we perform quantitative …

Gene expression requires tight coordination of the molecular machineries that mediate
transcription and splicing. While the interplay between transcription kinetics and spliceosome …

Aggregation of the multifunctional RNA‐binding protein TDP‐43 defines large subgroups of
amyotrophic lateral sclerosis and frontotemporal dementia and correlates with …

The neuronal RNA-binding protein Ptbp2 regulates neuronal differentiation by modulating
alternative splicing programs in the nucleus. Such programs contribute to axonogenesis by …

Proteins carry out the vast majority of functions in all biological domains, but for technological
reasons their large-scale investigation has lagged behind the study of genomes. Since the …

Plasma and serum are rich sources of information regarding an individual's health state,
and protein tests inform medical decision making. Despite major investments, few new …

Frontotemporal dementia and amyotrophic lateral sclerosis patients with C9orf72 mutation
show cytoplasmic poly-GR and poly-PR aggregates. Short poly-(Gly-Arg) and poly-(Pro-Arg) (…

Neurons critically rely on the functions of RNA-binding proteins to maintain their polarity and
resistance to neurotoxic stress. HnRNP R has a diverse range of post-transcriptional …

Huntington’s disease (HD) is a devastating hereditary movement disorder, characterized by
degeneration of neurons in the striatum and cortex. Studies in human patients and mouse …