DNA methyltransferase (cytosine-5) 1 (Dnmt1) is the principal enzyme responsible for
maintenance of CpG methylation and is essential for the regulation of gene expression, silencing …

The Polycomb-group (PcG) repressive complex-1 (PRC1) forms microscopically visible
clusters in nuclei; however, the impact of this cluster formation on transcriptional regulation and …

Repression of endogenous retroviruses (ERVs) in mammals involves several epigenetic
mechanisms. Acute loss of the maintenance methyltransferase Dnmt1 induces widespread …

Many microRNAs (miRNAs) are evolutionarily conserved and have intriguing expression
patterns. Tissue and/or time-specific expressions of some miRNAs are presumably controlled …

Faithful propagation of DNA methylation patterns during DNA replication is critical for
maintaining cellular phenotypes of individual differentiated cells 1 , 2 , 3 , 4 , 5 . Although it is well …

The mechanisms by which the major Polycomb group (PcG) complexes PRC1 and PRC2
are recruited to target sites in vertebrate cells are not well understood. Building on recent …

Two distinct Polycomb complexes, PRC1 and PRC2, collaborate to maintain epigenetic
repression of key developmental loci in embryonic stem cells (ESCs). PRC1 and PRC2 have …

Concomitant activation of the Wnt pathway and suppression of Mapk signalling by two small
molecule inhibitors (2i) in the presence of leukaemia inhibitory factor (LIF) (hereafter termed …

Intestinal regulatory T cells (T reg cells) are necessary for the suppression of excessive
immune responses to commensal bacteria. However, the molecular machinery that controls the …

The human brain is a complex, three‐dimensional structure. To better recapitulate brain
complexity, recent efforts have focused on the development of human‐specific midbrain …