User profiles for J. Wells

James A. Wells

- Verified email at ucsf.edu - Cited by 69803

Jonathan CK Wells

- Verified email at ucl.ac.uk - Cited by 42939

Jerry M Wells

- Verified email at wur.nl - Cited by 22235

Correlates of physical activity: why are some people physically active and others not?

AE Bauman, RS Reis, JF Sallis, JC Wells, RJF Loos… - The lancet, 2012 - thelancet.com
Physical inactivity is an important contributor to non-communicable diseases in countries of
high income, and increasingly so in those of low and middle income. Understanding why …

[HTML][HTML] Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

…, R Bannister, HC Hui, N Larson, R Strickley, J Wells… - Nature, 2016 - nature.com
… four wells of infected untreated cells and four wells of … replaced with 100 μl per well of media
containing the appropriate … Vero cell monolayers in 96-well plates to determine the tissue …

[HTML][HTML] Intestinal permeability–a new target for disease prevention and therapy

…, M Serino, H Tilg, A Watson, JM Wells - BMC …, 2014 - Springer
… The barrier assessments are further hindered by the natural variability of this functional entity
depending on species and genes as well as on diet and other environmental factors. In the …

Reaching for high-hanging fruit in drug discovery at protein–protein interfaces

JA Wells, CL McClendon - Nature, 2007 - nature.com
… These small molecules do not bind well to other anti-apoptotic members of the Bcl-2 family
such as MCL1 (myeloid cell leukaemia sequence 1) and Bcl-B 46 . The most potent of these, …

[HTML][HTML] Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430

TK Warren, J Wells, RG Panchal, KS Stuthman… - Nature, 2014 - nature.com
Filoviruses are emerging pathogens and causative agents of viral haemorrhagic fever. Case
fatality rates of filovirus disease outbreaks are among the highest reported for any human …

[HTML][HTML] A systematic screen of FDA-approved drugs for inhibitors of biological threat agents

…, S Bavari, RG Panchal, TK Warren, JB Wells… - PloS one, 2013 - journals.plos.org
… goal, since currently approved drugs already have well-established safety and pharmacokinetic
profiles in patients, as well as manufacturing and distribution networks. Therefore, …

Advanced antisense therapies for postexposure protection against lethal filovirus infections

TK Warren, KL Warfield, J Wells, DL Swenson… - Nature medicine, 2010 - nature.com
Currently, no vaccines or therapeutics are licensed to counter Ebola or Marburg viruses, highly
pathogenic filoviruses that are causative agents of viral hemorrhagic fever. Here we show …

Antiviral activity of hop constituents against a series of DNA and RNA viruses

…, J Wells, L Chuvala, S Sloane, R Paulman, J Russell… - Antiviral research, 2004 - Elsevier
We investigated whether crude hop extracts and purified hop components representing every
major chemical class of hop compound have antiviral activity. These hop constituents were …

Cross-national epidemiology of major depression and bipolar disorder

…, JP Lepine, SC Newman, M Rubio-Stipec, JE Wells… - Jama, 1996 - jamanetwork.com
Objective. —To estimate the rates and patterns of major depression and bipolar disorder
based on cross-national epidemiologic surveys. Design and Setting. —Population-based …

Prevalence and correlates of bipolar spectrum disorder in the world mental health survey initiative

…, J Posada-Villa, R Sagar, JE Wells… - Archives of general …, 2011 - jamanetwork.com
Context There is limited information on the prevalence and correlates of bipolar spectrum
disorder in international population-based studies using common methods. Objectives To …